Rv3634c from Mycobacterium tuberculosis H37Rv encodes an enzyme with UDP-Gal/Glc and UDP-GalNAc 4-epimerase activities

A bioinformatics study revealed that Mycobacterium tuberculosis H37Rv (Mtb) contains sequence homologs of Campylobacter jejuni protein glycosylation enzymes. The ORF Rv3634c from Mtb was identified as a sequence homolog of C. jejuni UDP-Gal/GalNAc 4-epimerase. This study reports the cloning of Rv363...

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Veröffentlicht in:	PloS one 2017-04, Vol.12 (4), p.e0175193-e0175193
Hauptverfasser:	Pardeshi, Peehu, Rao, K Krishnamurthy, Balaji, Petety V
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrylamide Alignment Amino Acid Sequence Amino acids Arabinogalactan B7 antigen Bacon Bacteria Biochemistry Bioengineering Bioinformatics Biological activity Biology and Life Sciences Biosynthesis Cadmium Calcium Calcium chloride Campylobacter jejuni - chemistry Campylobacter jejuni - enzymology Campylobacter jejuni - genetics Campylobacter jejuni - metabolism Carbohydrate Epimerases - chemistry Carbohydrate Epimerases - genetics Carbohydrate Epimerases - metabolism Catalysis Cell surface Chemicals Cholesterol Cloning Cloning, Molecular Computational biology Computer programs Cytology Cytoplasm Dehydrogenase Deoxyribonucleic acid DNA DNA polymerase E coli Enzymatic activity Enzymes Functional analysis Fungi Gene expression Gene mapping Genomes Genomics Glucose High resolution Homology Humans Immunoglobulin E Infections Inflammation Integrated circuits Kinases Liquid chromatography Markers Metabolism Molecular weight Mutagenesis, Site-Directed Mutants Mutation Mycobacterium tuberculosis Mycobacterium tuberculosis - chemistry Mycobacterium tuberculosis - enzymology Mycobacterium tuberculosis - genetics Mycobacterium tuberculosis - metabolism Network analysis Nucleotide sequence Peptides Phenols Physical sciences Point Mutation Prokaryotes Protein Conformation Proteins Proteomics Recombinant Proteins - chemistry Recombinant Proteins - genetics Recombinant Proteins - metabolism Research and Analysis Methods Residues Sequence Alignment Site-directed mutagenesis Spectroscopy Substrates Surgical implants Transcription Tuberculosis Tuberculosis - microbiology UDPglucose 4-Epimerase - chemistry UDPglucose 4-Epimerase - genetics UDPglucose 4-Epimerase - metabolism
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