Transmembrane domain quality control systems operate at the endoplasmic reticulum and Golgi apparatus

Multiple protein quality control systems operate to ensure that misfolded proteins are efficiently cleared from the cell. While quality control systems that assess the folding status of soluble domains have been extensively studied, transmembrane domain (TMD) quality control mechanisms are poorly un...

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Veröffentlicht in:	PloS one 2017-04, Vol.12 (4), p.e0173924-e0173924
Hauptverfasser:	Briant, Kit, Johnson, Nicholas, Swanton, Eileithyia
Format:	Artikel
Sprache:	eng
Schlagworte:	Aberration Amino acids Animals Assembly Biochemistry Biology Biology and Life Sciences Biosynthesis Brefeldin A Calnexin Cargo CD8 antigen Cell surface Chaperones Control systems Cytosol Defects Degradation Endoplasmic reticulum Endoplasmic Reticulum - metabolism Engineering and Technology Exposure Folding Glycoproteins Golgi apparatus Golgi Apparatus - metabolism Hydrophobicity Integration Lipids Localization Lysosomes Machinery Mammalian cells Mammals Medicine Membrane proteins Misalignment Molecular biology Molecular modelling Organic chemistry Peptides Proteins Quality Control Quality control equipment Recognition Recycling Research and Analysis Methods Residues Retention Rodents Science Substrates Traffic Translation Translocation Transmembrane domains Ubiquitin-protein ligase Vacuoles Vesicles Viruses Yeast
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