Generation and characterization of epoxide hydrolase 3 (EPHX3)-deficient mice

Cytochrome P450 (CYP) epoxygenases metabolize arachidonic acid into epoxyeicosatrienoic acids (EETs), which play an important role in blood pressure regulation, protection against ischemia-reperfusion injury, angiogenesis, and inflammation. Epoxide hydrolases metabolize EETs to their corresponding d...

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Veröffentlicht in:	PloS one 2017-04, Vol.12 (4), p.e0175348
Hauptverfasser:	Hoopes, Samantha L, Gruzdev, Artiom, Edin, Matthew L, Graves, Joan P, Bradbury, J Alyce, Flake, Gordon P, Lih, Fred B, DeGraff, Laura M, Zeldin, Darryl C
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Alveoli Angiogenesis Animals Arachidonic acid Biology and Life Sciences Blood pressure Body Weight Bronchus Cancer Cytochrome Cytochrome P450 Cytochromes P450 Diols Disruption Endothelium Environmental health Enzymes Epoxide hydrolase Epoxide Hydrolases - genetics Epoxide Hydrolases - physiology Epoxides Esophagus Exons Fatty acids Female Gene expression Genotypes Health sciences Heart Histology Homology Hydrolases Hydrolysis Inflammation - chemically induced Inflammation - metabolism Ischemia Lipids Lipopolysaccharides Lipopolysaccharides - pharmacology Lungs Lysates Male Medicine and Health Sciences Metabolism Mice Mice, Knockout Nematodes Organ Size Physical Sciences Plasma levels Recovery of function Reperfusion Reverse Transcriptase Polymerase Chain Reaction Rodents Skin Stomach Tongue
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