Biodegradable poly (lactic acid-co-glycolic acid) scaffolds as carriers for genetically-modified fibroblasts

Recent advances in gene delivery into cells allow improved therapeutic effects in gene therapy trials. To increase the bioavailability of applied cells, it is of great interest that transfected cells remain at the application site and systemic spread is minimized. In this study, we tested clinically...

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Veröffentlicht in:	PloS one 2017-04, Vol.12 (4), p.e0174860
Hauptverfasser:	Perisic, Tatjana, Zhang, Ziyang, Foehr, Peter, Hopfner, Ursula, Klutz, Kathrin, Burgkart, Rainer H, Slobodianski, Alexei, Goeldner, Moritz, Machens, Hans-Günther, Schilling, Arndt F
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Bioavailability Biodegradability Biodegradation Biology and Life Sciences Biomechanical engineering Biomechanics Biomedical materials Cell Adhesion Cell Engineering Cell Line Cell Proliferation Cultivation Engineering Fibroblasts Fibroblasts - physiology Fluorescence Gene expression Gene therapy Gene transfer Genetic Engineering Genetic modification Glycolic acid Green fluorescent protein Green Fluorescent Proteins - metabolism Growth factors Hand surgery Health aspects Humans Lactic acid Lactic Acid - chemistry Mechanical properties Medicine and Health Sciences Physiological aspects Plastic surgery Polyglycolic Acid - chemistry Polylactic acid Polylactic Acid-Polyglycolic Acid Copolymer Polylactide-co-glycolide Polymers Proteins Regeneration Regenerative medicine Research and Analysis Methods Scaffolds Secretion Skin Tissue engineering Tissue Scaffolds Vascular endothelial growth factor Vascular Endothelial Growth Factor A - metabolism Volumetric analysis
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