All-trans retinoic acid suppresses the angiopoietin-Tie2 pathway and inhibits angiogenesis and metastasis in esophageal squamous cell carcinoma

Esophageal squamous cell carcinoma (ESCC) is the second common cancer in Henan province and is well-known for aggressiveness and dismal prognosis. Adjuvant therapies, chemotherapy, radiotherapy and endoscopic treatment have not improved survival rates in patients with late stage esophageal carcinoma...

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Veröffentlicht in:	PloS one 2017-04, Vol.12 (4), p.e0174555
Hauptverfasser:	Li, Na, Lu, Yanjuan, Li, Daoming, Zheng, Xiangyu, Lian, Jingyao, Li, Shanshan, Cui, Huijuan, Zhang, Linda, Sang, Luqian, Wang, Ying, Yu, Jane J, Lu, Taiying
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Fluorouracil Acids Adjuvant chemotherapy Analysis Angiogenesis Angiopoietin Angiopoietin-1 - biosynthesis Animal models Animals Antineoplastic Agents - pharmacology Apoptosis Biological activity Biology and Life Sciences Cachexia Cancer therapies Carcinoma, Squamous Cell - drug therapy Care and treatment Cell Line, Tumor Cell Movement - drug effects Cell Proliferation - drug effects Cellular biology Chemical compounds Chemotherapy Diagnosis Esophageal cancer Esophageal carcinoma Esophageal Neoplasms - drug therapy Esophageal Squamous Cell Carcinoma Esophagus Female Fluorouracil - pharmacology Gene expression Health aspects Humans Immune response In vitro methods and tests Lung cancer Lungs Medicine and Health Sciences Metastases Metastasis Mice Mice, Inbred BALB C Neoplasm Metastasis - drug therapy Neovascularization, Pathologic - drug therapy Pharmacology Physical Sciences Platelet Endothelial Cell Adhesion Molecule-1 - biosynthesis Polymerase chain reaction Prognosis Radiation therapy Radiotherapy Receptor, TIE-2 - biosynthesis Receptors Receptors, Vascular Endothelial Growth Factor - biosynthesis Reproduction (biology) Retinoic acid Squamous cell carcinoma Survival Transcription Tretinoin Tretinoin - pharmacology Tumors Vascular endothelial growth factor Vascular Endothelial Growth Factor A - biosynthesis Vesicular Transport Proteins - biosynthesis Viability Vitamin A Xenografts
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