Low-cost feedback-controlled syringe pressure pumps for microfluidics applications
Microfluidics are widely used in research ranging from bioengineering and biomedical disciplines to chemistry and nanotechnology. As such, there are a large number of options for the devices used to drive and control flow through microfluidic channels. Commercially available syringe pumps are probab...
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| Veröffentlicht in: | PloS one 2017-04, Vol.12 (4), p.e0175089-e0175089 |
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| creator | Lake, John R Heyde, Keith C Ruder, Warren C |
| description | Microfluidics are widely used in research ranging from bioengineering and biomedical disciplines to chemistry and nanotechnology. As such, there are a large number of options for the devices used to drive and control flow through microfluidic channels. Commercially available syringe pumps are probably the most commonly used instruments for this purpose, but are relatively high-cost and have inherent limitations due to their flow profiles when they are run open-loop. Here, we present a low-cost ($110) syringe pressure pump that uses feedback control to regulate the pressure into microfluidic chips. Using an open-source microcontroller board (Arduino), we demonstrate an easily operated and programmable syringe pump that can be run using either a PID or bang-bang control method. Through feedback control of the pressure at the inlets of two microfluidic geometries, we have shown stability of our device to within ±1% of the set point using a PID control method and within ±5% of the set point using a bang-bang control method with response times of less than 1 second. This device offers a low-cost option to drive and control well-regulated pressure-driven flow through microfluidic chips. |
| doi_str_mv | 10.1371/journal.pone.0175089 |
| format | Article |
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As such, there are a large number of options for the devices used to drive and control flow through microfluidic channels. Commercially available syringe pumps are probably the most commonly used instruments for this purpose, but are relatively high-cost and have inherent limitations due to their flow profiles when they are run open-loop. Here, we present a low-cost ($110) syringe pressure pump that uses feedback control to regulate the pressure into microfluidic chips. Using an open-source microcontroller board (Arduino), we demonstrate an easily operated and programmable syringe pump that can be run using either a PID or bang-bang control method. Through feedback control of the pressure at the inlets of two microfluidic geometries, we have shown stability of our device to within ±1% of the set point using a PID control method and within ±5% of the set point using a bang-bang control method with response times of less than 1 second. This device offers a low-cost option to drive and control well-regulated pressure-driven flow through microfluidic chips.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0175089</identifier><identifier>PMID: 28369134</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Analytical chemistry ; Bioengineering ; Biology ; Computer and Information Sciences ; Control equipment ; Control methods ; Control stability ; Control systems ; Design ; Drug infusion pumps ; Engineering and Technology ; Feedback ; Feedback control ; Feedback control systems ; Flow control ; Flow profiles ; Infusion Pumps ; Inlets ; Lab-On-A-Chip Devices ; Laboratories ; Low cost ; Methods ; Microfluidics ; Microfluidics - instrumentation ; Nanotechnology ; Off-on control ; Performance evaluation ; Physical Sciences ; Pressure ; Proportional integral derivative ; Pumps ; Researchers ; Science ; Science Policy ; Sensors ; Studies ; Syringes</subject><ispartof>PloS one, 2017-04, Vol.12 (4), p.e0175089-e0175089</ispartof><rights>COPYRIGHT 2017 Public Library of Science</rights><rights>2017 Lake et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2017 Lake et al 2017 Lake et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-fd0579551827743713c83447bc74df950478ffc0f0023d45a8a10137b7a31e2e3</citedby><cites>FETCH-LOGICAL-c692t-fd0579551827743713c83447bc74df950478ffc0f0023d45a8a10137b7a31e2e3</cites><orcidid>0000-0003-0745-9933</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5378403/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5378403/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79343,79344</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28369134$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Wanunu, Meni</contributor><creatorcontrib>Lake, John R</creatorcontrib><creatorcontrib>Heyde, Keith C</creatorcontrib><creatorcontrib>Ruder, Warren C</creatorcontrib><title>Low-cost feedback-controlled syringe pressure pumps for microfluidics applications</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Microfluidics are widely used in research ranging from bioengineering and biomedical disciplines to chemistry and nanotechnology. As such, there are a large number of options for the devices used to drive and control flow through microfluidic channels. Commercially available syringe pumps are probably the most commonly used instruments for this purpose, but are relatively high-cost and have inherent limitations due to their flow profiles when they are run open-loop. Here, we present a low-cost ($110) syringe pressure pump that uses feedback control to regulate the pressure into microfluidic chips. Using an open-source microcontroller board (Arduino), we demonstrate an easily operated and programmable syringe pump that can be run using either a PID or bang-bang control method. Through feedback control of the pressure at the inlets of two microfluidic geometries, we have shown stability of our device to within ±1% of the set point using a PID control method and within ±5% of the set point using a bang-bang control method with response times of less than 1 second. This device offers a low-cost option to drive and control well-regulated pressure-driven flow through microfluidic chips.</description><subject>Analytical chemistry</subject><subject>Bioengineering</subject><subject>Biology</subject><subject>Computer and Information Sciences</subject><subject>Control equipment</subject><subject>Control methods</subject><subject>Control stability</subject><subject>Control systems</subject><subject>Design</subject><subject>Drug infusion pumps</subject><subject>Engineering and Technology</subject><subject>Feedback</subject><subject>Feedback control</subject><subject>Feedback control systems</subject><subject>Flow control</subject><subject>Flow profiles</subject><subject>Infusion Pumps</subject><subject>Inlets</subject><subject>Lab-On-A-Chip Devices</subject><subject>Laboratories</subject><subject>Low cost</subject><subject>Methods</subject><subject>Microfluidics</subject><subject>Microfluidics - 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One</addtitle><date>2017-04-03</date><risdate>2017</risdate><volume>12</volume><issue>4</issue><spage>e0175089</spage><epage>e0175089</epage><pages>e0175089-e0175089</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Microfluidics are widely used in research ranging from bioengineering and biomedical disciplines to chemistry and nanotechnology. As such, there are a large number of options for the devices used to drive and control flow through microfluidic channels. Commercially available syringe pumps are probably the most commonly used instruments for this purpose, but are relatively high-cost and have inherent limitations due to their flow profiles when they are run open-loop. Here, we present a low-cost ($110) syringe pressure pump that uses feedback control to regulate the pressure into microfluidic chips. Using an open-source microcontroller board (Arduino), we demonstrate an easily operated and programmable syringe pump that can be run using either a PID or bang-bang control method. Through feedback control of the pressure at the inlets of two microfluidic geometries, we have shown stability of our device to within ±1% of the set point using a PID control method and within ±5% of the set point using a bang-bang control method with response times of less than 1 second. This device offers a low-cost option to drive and control well-regulated pressure-driven flow through microfluidic chips.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>28369134</pmid><doi>10.1371/journal.pone.0175089</doi><tpages>e0175089</tpages><orcidid>https://orcid.org/0000-0003-0745-9933</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Analytical chemistry Bioengineering Biology Computer and Information Sciences Control equipment Control methods Control stability Control systems Design Drug infusion pumps Engineering and Technology Feedback Feedback control Feedback control systems Flow control Flow profiles Infusion Pumps Inlets Lab-On-A-Chip Devices Laboratories Low cost Methods Microfluidics Microfluidics - instrumentation Nanotechnology Off-on control Performance evaluation Physical Sciences Pressure Proportional integral derivative Pumps Researchers Science Science Policy Sensors Studies Syringes |
| title | Low-cost feedback-controlled syringe pressure pumps for microfluidics applications |
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