Mining expression and prognosis of topoisomerase isoforms in non-small-cell lung cancer by using Oncomine and Kaplan-Meier plotter

DNA topoisomerases are essential to modulate DNA topology during various cellular genetic processes. The expression and distinct prognostic value of topoisomerase isoforms in non-small-cell lung cancer (NSCLC) is not well established. In the current study, we have examined the mRNA expression of top...

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Veröffentlicht in:	PloS one 2017-03, Vol.12 (3), p.e0174515-e0174515
Hauptverfasser:	Hou, Guo-Xin, Liu, Panpan, Yang, Jing, Wen, Shijun
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute lymphoblastic leukemia Adenocarcinoma Adenocarcinoma - diagnosis Adenocarcinoma - enzymology Adenocarcinoma - mortality Archaea Biochemistry Biology and Life Sciences Biomarkers Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Breast cancer Breast carcinoma Cancer Cancer therapies Carcinoma, Squamous Cell - diagnosis Carcinoma, Squamous Cell - enzymology Carcinoma, Squamous Cell - mortality Chemotherapy Children Chromosomes Collaboration Copy number Cytotoxicity Damage Data Mining Databases, Nucleic Acid Deoxyribonucleic acid Diagnosis Differentiation DNA DNA repair DNA topoisomerase DNA Topoisomerases - genetics DNA Topoisomerases - metabolism Drugs Eukaryotes Gene Expression Gene Expression Profiling Genetic aspects Genomes Humans Inhibitors Isoenzymes Isoforms Kaplan-Meier Estimate Laboratories Leukemia Lung cancer Lung diseases Lung Neoplasms - diagnosis Lung Neoplasms - enzymology Lung Neoplasms - mortality Lungs Lymph nodes Lymphatic leukemia Medical prognosis Medical research Medicine Medicine and Health Sciences Metabolism Metastases Mice Mining Mitochondrial DNA Mitosis Non-small cell lung cancer Non-small cell lung carcinoma Oncology Ovarian cancer Ovarian carcinoma Pathology Patients Paving Pharmacology Prognosis Prostate cancer Quality of life Quantitation Radiation therapy Recombination Replication Ribonucleic acid RNA Squamous cell carcinoma Stability Strands Studies Supercoiling Survival Tissues Topology Toxicity Tumor cells
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