Effect of miR-146 targeted HDMCP up-regulation in the pathogenesis of nonalcoholic steatohepatitis

Mitochondrial dysfunction plays an important role inthe pathogenesis of nonalcoholic steatohepatitis (NASH), where uncoupling protein (UCP) is actively involved. We previously reported the uncoupling activity of HDMCP and its role in liver steatosis. We now aim to investigate the degree and therapeu...

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Veröffentlicht in:	PloS one 2017-03, Vol.12 (3), p.e0174218-e0174218
Hauptverfasser:	Jin, Xi, Liu, Jiang, Chen, Yi-Peng, Xiang, Zun, Ding, Jie-Xia, Li, You-Ming
Format:	Artikel
Sprache:	eng
Schlagworte:	AKT protein Alanine Alanine transaminase Alcoholic beverages Alcohols Animal models Animals Apoptosis Aspartate aminotransferase ATP BAX protein Bcl protein Bcl-2 protein Biochemical markers Biochemistry Bioengineering Biology and Life Sciences Biotechnology Body weight Breast cancer Carbon dioxide Care and treatment Cell Line Cholesterol Cytokines Declination Disease Models, Animal Fatty acids Fatty liver Flow cytometry Food Gastroenterology Gene expression Hepatology Hospitals Hydrogen peroxide Immune response Inflammation Inflammation - genetics Inflammation - pathology Interleukin 1 Interleukin 6 Laboratory animals Laboratory tests Liver Liver - metabolism Liver - pathology Liver diseases Liver transplantation Male Medical research Medicine Medicine and Health Sciences Metabolism Metastases Metastasis Mice Mice, Inbred BALB C MicroRNA MicroRNAs MicroRNAs - genetics Mitochondrial Membrane Transport Proteins - genetics Non-alcoholic Fatty Liver Disease - genetics Non-alcoholic Fatty Liver Disease - pathology Obesity Oils & fats Oxidative stress Oxygen consumption Pathogenesis Pathology Permeability Proteins Research and Analysis Methods Ribonucleic acid RNA RNA interference Rodents Transplantation Tumor necrosis factor-TNF Up-Regulation
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