Uniquely altered transcripts are associated with immune preservation in HIV infection

The mechanisms underlying host HIV control hold much promise in the search for a functional HIV cure. We investigated the host genomic signatures in elite controllers or rapid progressors following recent infection and the correlates of immune reconstitution during combination antiretroviral therapy...

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Veröffentlicht in:	PloS one 2017-03, Vol.12 (3), p.e0169868-e0169868
Hauptverfasser:	Zanoni, Michelle, Aventurato, Ítalo Karmann, Hunter, James, Sucupira, Maria Cecilia Araripe, Diaz, Ricardo Sobhie
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiretroviral agents Antiretroviral Therapy, Highly Active Antithrombin III - genetics Antithrombin III - immunology Antiviral Agents - therapeutic use Binding sites Biology and Life Sciences Bone marrow Brazil Care and treatment CD4 Lymphocyte Count Chemokines - genetics Chemokines - immunology Cohort Studies Control Controllers Cross-Priming - immunology Cytokines Cytokines - genetics Cytokines - immunology Elastase Gene expression Gene Expression Profiling - methods Health aspects Highly active antiretroviral therapy HIV HIV infections HIV Infections - drug therapy HIV Infections - genetics HIV Infections - immunology HIV Long-Term Survivors HIV-1 - drug effects HIV-1 - immunology HLA-B Antigens - immunology Host-Pathogen Interactions - drug effects Host-Pathogen Interactions - immunology Human immunodeficiency virus Humans Immunology Infections Inflammation Laboratories Leukocytes, Mononuclear - drug effects Leukocytes, Mononuclear - immunology Leukocytes, Mononuclear - metabolism Life expectancy Lymphocytes Lymphocytes T Medicine Medicine and Health Sciences Neutrophils Polymerase chain reaction Preservation Regression analysis Reverse Transcriptase Polymerase Chain Reaction Rodents T cells Therapy Transcriptome - drug effects Transcriptome - immunology
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