Differential recruitment efficacy of patient-derived amyloidogenic and myeloma light chain proteins by synthetic fibrils-A metric for predicting amyloid propensity

Monoclonal free light chain (LC) proteins are present in the circulation of patients with immunoproliferative disorders such as light chain (AL) amyloidosis and multiple myeloma (MM). Light chain-associated amyloid is a complex pathology composed of proteinaceous fibrils and extracellular matrix pro...

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Veröffentlicht in:	PloS one 2017-03, Vol.12 (3), p.e0174152-e0174152
Hauptverfasser:	Martin, Emily B, Williams, Angela, Wooliver, Craig, Heidel, R Eric, Adams, Sarah, Dunlap, John, Ramirez-Alvarado, Marina, Blancas-Mejia, Luis M, Lands, Ronald H, Kennel, Stephen J, Wall, Jonathan S
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age Aged Aged, 80 and over Agglomeration Amyloid - immunology Amyloid - metabolism Amyloid - ultrastructure Amyloid P component Amyloidogenesis Amyloidogenic Proteins - immunology Amyloidogenic Proteins - metabolism Amyloidosis Amyloidosis - immunology Amyloidosis - metabolism Antibodies Assaying Biochemistry Biocompatibility Biology Biology and Life Sciences Blood Blotting, Western Bone marrow Cancer Care and treatment Cell proliferation Constant region Cytotoxicity Death Diagnosis Drugs Electrophoresis, Polyacrylamide Gel Female Fibrillogenesis Fragmentation Gammopathy Heart Humans Immunoglobulin Light Chains - chemistry Immunoglobulin Light Chains - immunology Immunoglobulin Light Chains - metabolism Immunoglobulin Light-chain Amyloidosis Immunoglobulins Immunology Immunomodulation Immunotherapy Kidneys Light Longitudinal studies Male Medical prognosis Medicine Medicine and Health Sciences Metabolism Microscopy Microscopy, Immunoelectron Middle Aged Molecular biology Molecular structure Multiple myeloma Multiple Myeloma - immunology Multiple Myeloma - metabolism Organs Patient outcomes Patients Physical chemistry Physical Sciences Physiological aspects Physiological factors Plasmas (physics) Polyglutamine Position (location) Prognosis Protein Binding Protein Multimerization - drug effects Proteins Radiology Renal function Research and Analysis Methods Risk Skin Stability Statistical analysis Surface Plasmon Resonance Surgery Survival Thermal stability Thermodynamics Toxicity Urea - pharmacology β-Amyloid
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