Correlation between clinical severity and different non-invasive measurements of carbon monoxide concentration: A population study
Carbon monoxide (CO) poisoning is a major concern in industrialized countries. Each year, thousands of victims, resulting in approximately 100 fatalities, are encountered in France. The diagnosis of CO poisoning is challenging; while carboxyhemoglobin (COHb) may be useful, it is a weak indicator of...
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| description | Carbon monoxide (CO) poisoning is a major concern in industrialized countries. Each year, thousands of victims, resulting in approximately 100 fatalities, are encountered in France. The diagnosis of CO poisoning is challenging; while carboxyhemoglobin (COHb) may be useful, it is a weak indicator of the severity of CO poisoning. This weak indicator may be a result of the delay between poisoning occurrence and the blood assay. Two apparatuses, CO oximeters and exhaled CO analyzers, now permit COHb to be determined outside hospitals. Our hypothesis is that these instruments allow the early measurement of COHb concentrations, which are more correlated with the severity of poisoning, expressed using the poisoning severity score (PSS).
In an observational and retrospective cohort study, the distribution of COHb measurements obtained by CO oximetry or by exhaled CO analyzers was compared between groups of severity expressed using the PSS.
Data were collected in the Paris area from January 2006 to December 2010 by the French Surveillance System of CO poisoning.
All patients with CO poisoning reported to the French Surveillance System of CO poisoning.
There was a significant difference in the COHb values obtained by CO oximetry between groups stratified according to PSS (p |
| doi_str_mv | 10.1371/journal.pone.0174672 |
| format | Article |
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In an observational and retrospective cohort study, the distribution of COHb measurements obtained by CO oximetry or by exhaled CO analyzers was compared between groups of severity expressed using the PSS.
Data were collected in the Paris area from January 2006 to December 2010 by the French Surveillance System of CO poisoning.
All patients with CO poisoning reported to the French Surveillance System of CO poisoning.
There was a significant difference in the COHb values obtained by CO oximetry between groups stratified according to PSS (p<0.0001). A significant difference in the values of exhaled CO was also observed between PSS groups (p = 0.006), although the relationship was not linear.
The COHb concentrations measured using CO oximetry, but not those measured using exhaled CO analyzers, were well correlated with the severity of CO poisoning.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0174672</identifier><identifier>PMID: 28350859</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adolescent ; Adult ; Analyzers ; Biology and Life Sciences ; Carbon monoxide ; Carbon Monoxide - blood ; Carbon monoxide poisoning ; Carbon Monoxide Poisoning - blood ; Carbon Monoxide Poisoning - diagnosis ; Carboxyhemoglobin ; Carboxyhemoglobin - analysis ; Coma ; Consciousness ; Correlation analysis ; Diagnosis ; Emergency medical care ; Female ; France ; Health surveillance ; Humans ; Intensive care ; Male ; Measurement ; Medical electronics ; Medicine and Health Sciences ; Oximetry ; Oximetry - methods ; Oxygen therapy ; Patients ; Physical Sciences ; Poisoning ; Population studies ; Population Surveillance - methods ; Prevention ; Public health ; Retrospective Studies ; Risk factors ; Severity of Illness Index ; Surveillance ; Young Adult</subject><ispartof>PloS one, 2017-03, Vol.12 (3), p.e0174672-e0174672</ispartof><rights>COPYRIGHT 2017 Public Library of Science</rights><rights>2017 Hullin et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2017 Hullin et al 2017 Hullin et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-f20ce6e6cb8d4bcc501328e30b08fbe2c2cdb1d6ee0f40e6b630cc1fea0c56b73</citedby><cites>FETCH-LOGICAL-c692t-f20ce6e6cb8d4bcc501328e30b08fbe2c2cdb1d6ee0f40e6b630cc1fea0c56b73</cites><orcidid>0000-0003-0880-2318</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5370138/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5370138/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28350859$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Durante, William</contributor><creatorcontrib>Hullin, Thomas</creatorcontrib><creatorcontrib>Aboab, Jerome</creatorcontrib><creatorcontrib>Desseaux, Kristell</creatorcontrib><creatorcontrib>Chevret, Sylvie</creatorcontrib><creatorcontrib>Annane, Djillali</creatorcontrib><title>Correlation between clinical severity and different non-invasive measurements of carbon monoxide concentration: A population study</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Carbon monoxide (CO) poisoning is a major concern in industrialized countries. Each year, thousands of victims, resulting in approximately 100 fatalities, are encountered in France. The diagnosis of CO poisoning is challenging; while carboxyhemoglobin (COHb) may be useful, it is a weak indicator of the severity of CO poisoning. This weak indicator may be a result of the delay between poisoning occurrence and the blood assay. Two apparatuses, CO oximeters and exhaled CO analyzers, now permit COHb to be determined outside hospitals. Our hypothesis is that these instruments allow the early measurement of COHb concentrations, which are more correlated with the severity of poisoning, expressed using the poisoning severity score (PSS).
In an observational and retrospective cohort study, the distribution of COHb measurements obtained by CO oximetry or by exhaled CO analyzers was compared between groups of severity expressed using the PSS.
Data were collected in the Paris area from January 2006 to December 2010 by the French Surveillance System of CO poisoning.
All patients with CO poisoning reported to the French Surveillance System of CO poisoning.
There was a significant difference in the COHb values obtained by CO oximetry between groups stratified according to PSS (p<0.0001). A significant difference in the values of exhaled CO was also observed between PSS groups (p = 0.006), although the relationship was not linear.
The COHb concentrations measured using CO oximetry, but not those measured using exhaled CO analyzers, were well correlated with the severity of CO poisoning.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Analyzers</subject><subject>Biology and Life Sciences</subject><subject>Carbon monoxide</subject><subject>Carbon Monoxide - blood</subject><subject>Carbon monoxide poisoning</subject><subject>Carbon Monoxide Poisoning - blood</subject><subject>Carbon Monoxide Poisoning - diagnosis</subject><subject>Carboxyhemoglobin</subject><subject>Carboxyhemoglobin - analysis</subject><subject>Coma</subject><subject>Consciousness</subject><subject>Correlation analysis</subject><subject>Diagnosis</subject><subject>Emergency medical care</subject><subject>Female</subject><subject>France</subject><subject>Health surveillance</subject><subject>Humans</subject><subject>Intensive care</subject><subject>Male</subject><subject>Measurement</subject><subject>Medical electronics</subject><subject>Medicine and Health Sciences</subject><subject>Oximetry</subject><subject>Oximetry - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hullin, Thomas</au><au>Aboab, Jerome</au><au>Desseaux, Kristell</au><au>Chevret, Sylvie</au><au>Annane, Djillali</au><au>Durante, William</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Correlation between clinical severity and different non-invasive measurements of carbon monoxide concentration: A population study</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2017-03-28</date><risdate>2017</risdate><volume>12</volume><issue>3</issue><spage>e0174672</spage><epage>e0174672</epage><pages>e0174672-e0174672</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Carbon monoxide (CO) poisoning is a major concern in industrialized countries. Each year, thousands of victims, resulting in approximately 100 fatalities, are encountered in France. The diagnosis of CO poisoning is challenging; while carboxyhemoglobin (COHb) may be useful, it is a weak indicator of the severity of CO poisoning. This weak indicator may be a result of the delay between poisoning occurrence and the blood assay. Two apparatuses, CO oximeters and exhaled CO analyzers, now permit COHb to be determined outside hospitals. Our hypothesis is that these instruments allow the early measurement of COHb concentrations, which are more correlated with the severity of poisoning, expressed using the poisoning severity score (PSS).
In an observational and retrospective cohort study, the distribution of COHb measurements obtained by CO oximetry or by exhaled CO analyzers was compared between groups of severity expressed using the PSS.
Data were collected in the Paris area from January 2006 to December 2010 by the French Surveillance System of CO poisoning.
All patients with CO poisoning reported to the French Surveillance System of CO poisoning.
There was a significant difference in the COHb values obtained by CO oximetry between groups stratified according to PSS (p<0.0001). A significant difference in the values of exhaled CO was also observed between PSS groups (p = 0.006), although the relationship was not linear.
The COHb concentrations measured using CO oximetry, but not those measured using exhaled CO analyzers, were well correlated with the severity of CO poisoning.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>28350859</pmid><doi>10.1371/journal.pone.0174672</doi><tpages>e0174672</tpages><orcidid>https://orcid.org/0000-0003-0880-2318</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Analyzers Biology and Life Sciences Carbon monoxide Carbon Monoxide - blood Carbon monoxide poisoning Carbon Monoxide Poisoning - blood Carbon Monoxide Poisoning - diagnosis Carboxyhemoglobin Carboxyhemoglobin - analysis Coma Consciousness Correlation analysis Diagnosis Emergency medical care Female France Health surveillance Humans Intensive care Male Measurement Medical electronics Medicine and Health Sciences Oximetry Oximetry - methods Oxygen therapy Patients Physical Sciences Poisoning Population studies Population Surveillance - methods Prevention Public health Retrospective Studies Risk factors Severity of Illness Index Surveillance Young Adult |
| title | Correlation between clinical severity and different non-invasive measurements of carbon monoxide concentration: A population study |
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