A genome-wide association study of thyroid stimulating hormone and free thyroxine in Danish children and adolescents

Hypothyroidism is associated with obesity, and thyroid hormones are involved in the regulation of body composition, including fat mass. Genome-wide association studies (GWAS) in adults have identified 19 and 6 loci associated with plasma concentrations of thyroid stimulating hormone (TSH) and free t...

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Veröffentlicht in:	PloS one 2017-03, Vol.12 (3), p.e0174204-e0174204
Hauptverfasser:	Nielsen, Tenna Ruest Haarmark, Appel, Emil Vincent Rosenbaum, Svendstrup, Mathilde, Ohrt, Johanne Dam, Dahl, Maria, Fonvig, Cilius Esmann, Hollensted, Mette, Have, Christian Theil, Kadarmideen, Haja N, Pedersen, Oluf, Hansen, Torben, Holm, Jens-Christian, Grarup, Niels
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adolescents Adult Adults Age Factors Analysis Biology and Life Sciences Body composition Body fat Body Mass Index Body weight Child Child, Preschool Children Denmark Endocrinology Female Gene expression Genetic aspects Genetic diversity Genetic Loci - genetics Genetic Loci - physiology Genetic Markers - genetics Genetic Predisposition to Disease - genetics Genetic variance Genetics Genome-wide association studies Genomes Genotypes Haplotypes Hormones Hospitals Humans Hypothyroidism Influence Laws, regulations and rules Loci Male Medicine and Health Sciences Meta-analysis Metabolism Obesity Overweight Pediatric Obesity - blood Pediatric Obesity - genetics Pediatrics People and Places Physical Sciences Physiological aspects Physiology Polymorphism, Single Nucleotide - genetics Population studies Replication Research and Analysis Methods Single-nucleotide polymorphism Studies Teenagers Thyroid Thyroid gland Thyroid hormones Thyroid-stimulating hormone Thyrotropin Thyrotropin - blood Thyroxine Thyroxine - blood Young Adult Young adults
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