Tracking the stochastic fate of cells of the renin lineage after podocyte depletion using multicolor reporters and intravital imaging

Podocyte depletion plays a major role in focal segmental glomerular sclerosis (FSGS). Because cells of the renin lineage (CoRL) serve as adult podocyte and parietal epithelial cell (PEC) progenitor candidates, we generated Ren1cCre/R26R-ConfettiTG/WT and Ren1dCre/R26R-ConfettiTG/WT mice to determine...

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Veröffentlicht in:	PloS one 2017-03, Vol.12 (3), p.e0173891-e0173891
Hauptverfasser:	Kaverina, Natalya V, Kadoya, Hiroyuki, Eng, Diana G, Rusiniak, Michael E, Sequeira-Lopez, Maria Luisa S, Gomez, R Ariel, Pippin, Jeffrey W, Gross, Kenneth W, Peti-Peterdi, Janos, Shankland, Stuart J
Format:	Artikel
Sprache:	eng
Schlagworte:	Abdomen Adult Stem Cells - cytology Adult Stem Cells - metabolism Animals Biology and Life Sciences Biophysics Cell Lineage Cell Movement Cellular biology Claudin-1 - metabolism Cyclin-Dependent Kinase Inhibitor p57 - metabolism Depletion Disease Models, Animal Epithelial cells Epithelial Cells - cytology Epithelial Cells - metabolism Female Genetic aspects Glomerulosclerosis, Focal Segmental - metabolism Glomerulosclerosis, Focal Segmental - pathology Glomerulus Intracellular Signaling Peptides and Proteins - metabolism Intravital Microscopy Kidney Glomerulus - cytology Kidney Glomerulus - metabolism Laboratories Medicine Medicine and Health Sciences Membrane Proteins - metabolism Mesangium Mice Mice, Transgenic Microscopy Microscopy, Fluorescence, Multiphoton Nephrology Pax8 protein PAX8 Transcription Factor - metabolism Pediatrics Physiology Podocytes - cytology Podocytes - metabolism Proteins Renin Renin - metabolism Repressor Proteins - metabolism Research and Analysis Methods Rodents Sclerosis Stem cells Stochastic Processes Stochasticity WT1 Proteins
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