The microRNA-302b-inhibited insulin-like growth factor-binding protein 2 signaling pathway induces glioma cell apoptosis by targeting nuclear factor IA

MicroRNAs are small noncoding RNAs that post-transcriptionally control the expression of genes involved in glioblastoma multiforme (GBM) development. Although miR-302b functions as a tumor suppressor, its role in GBM is still unclear. Therefore, this study comprehensively explored the roles of miR-3...

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Veröffentlicht in:	PloS one 2017-03, Vol.12 (3), p.e0173890-e0173890
Hauptverfasser:	Lee, Chin-Cheng, Chen, Peng-Hsu, Ho, Kuo-Hao, Shih, Chwen-Ming, Cheng, Chia-Hsiung, Lin, Cheng-Wei, Cheng, Kur-Ta, Liu, Ann-Jeng, Chen, Ku-Chung
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine diphosphate Apoptosis Apoptosis - genetics Apoptosis - physiology Astrocytes Astrocytes - cytology Astrocytes - metabolism Biochemistry Biology Biology and Life Sciences Biotechnology Breast cancer Caspase Caspase-3 Cell culture Cell death Cell growth Cell Line, Tumor Cell Survival - genetics DNA microarrays Down-Regulation Gene expression Gene Knockdown Techniques Gene Regulatory Networks Genes Genetic aspects Genomics Glioblastoma Glioblastoma - genetics Glioblastoma - metabolism Glioblastoma - pathology Glioblastoma multiforme Glioblastomas Glioma Glioma - genetics Glioma - metabolism Glioma - pathology Glioma cells Humans Immunoglobulins Insulin Insulin-Like Growth Factor Binding Protein 2 - antagonists & inhibitors Insulin-Like Growth Factor Binding Protein 2 - genetics Insulin-Like Growth Factor Binding Protein 2 - metabolism Insulin-like growth factor I Insulin-like growth factor-binding protein 2 Insulin-like growth factors Kinases Medical research Medicine Medicine and Health Sciences MicroRNA MicroRNAs MicroRNAs - genetics MicroRNAs - metabolism miRNA Mortality NFI Transcription Factors - antagonists & inhibitors NFI Transcription Factors - genetics NFI Transcription Factors - metabolism Pharmacy Post-transcription Promoter Regions, Genetic Proteins Research and Analysis Methods Ribonucleic acid Ribose RNA Signal Transduction Signaling Stem cells Survival Target recognition Tissues Transcription factors Transcriptome Tumor cell lines Tumor suppressor genes Tumorigenesis
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