Role of muscle IL-6 in gender-specific metabolism in mice

The aim of the present work was to further explore the physiological roles of muscle-derived IL-6. Adult-floxed and conditional skeletal muscle IL-6 knock out male and female mice were used to study energy expenditure (indirect calorimetry at rest and during treadmill exercise, and body temperature...

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Veröffentlicht in:	PloS one 2017-03, Vol.12 (3), p.e0173675-e0173675
Hauptverfasser:	Molinero, Amalia, Fernandez-Perez, Antonio, Mogas, Aina, Giralt, Mercedes, Comes, Gemma, Fernandez-Gayol, Olaya, Vallejo, Mario, Hidalgo, Juan
Format:	Artikel
Sprache:	eng
Schlagworte:	AKT protein Analysis Animals Biology and Life Sciences Body fat Body Temperature Body weight Calorimetry Carbon dioxide Cellular biology Cellular stress response Citrate synthase Cytokines Diabetes Energy Energy balance Energy expenditure Energy intake Energy measurement Energy Metabolism Exercise Exercise Test Fasting - metabolism Fasting - physiology Fatty acids Females Fitness equipment Food Food consumption Gender Gender differences Gene expression Gene Knockout Techniques Homeostasis Immunology Insulin Insulin - metabolism Insulin resistance Interleukin 6 Interleukin-6 - deficiency Interleukin-6 - genetics Interleukin-6 - metabolism Leptin Light Liver Male Males Medicine and Health Sciences Metabolism Mice Muscle, Skeletal - metabolism Muscles Musculoskeletal system Neurosciences Obesity Phosphorylation Physical fitness Physiological aspects Physiology Proto-Oncogene Proteins c-akt - chemistry Proto-Oncogene Proteins c-akt - metabolism Research and Analysis Methods Rest Rodents Serine - metabolism Sex Characteristics Sex differences Signal Transduction Signaling Skeletal muscle Stress, Physiological - drug effects Temperature Tricarboxylic acid cycle Weight reduction
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