Loss of c-KIT expression in thyroid cancer cells

Papillary thyroid carcinoma is the most frequent histologic type of thyroid tumor. Few studies investigated the role of c-KIT expression in thyroid tumors, suggesting a role for this receptor and its ligand in differentiation and growth control of thyroid epithelium and a receptor loss following mal...

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Veröffentlicht in:	PloS one 2017-03, Vol.12 (3), p.e0173913-e0173913
Hauptverfasser:	Franceschi, Sara, Lessi, Francesca, Panebianco, Federica, Tantillo, Elena, La Ferla, Marco, Menicagli, Michele, Aretini, Paolo, Apollo, Alessandro, Naccarato, Antonio Giuseppe, Marchetti, Ivo, Mazzanti, Chiara Maria
Format:	Artikel
Sprache:	eng
Schlagworte:	Benign Biology and Life Sciences c-Kit protein Carcinoma - metabolism Carcinoma - pathology Carcinoma, Papillary Cell Differentiation Cell Line, Tumor Cell Proliferation Cellular biology Cloning Differentiation Epithelium Gene expression Genetic aspects Genetic transformation Hospitals Humans Kinases Ligands Malignancy Medicine Medicine and Health Sciences Messenger RNA Mitogen-activated protein kinases Mutation Nuclear Proteins - metabolism Papillary thyroid carcinoma Pax8 protein PAX8 Transcription Factor - metabolism Proto-Oncogene Proteins c-kit - genetics Proto-Oncogene Proteins c-kit - metabolism Research and analysis methods Science Signal transduction Surgery Thyrocytes Thyroid Thyroid cancer Thyroid Cancer, Papillary Thyroid Neoplasms - metabolism Thyroid Neoplasms - pathology Thyroid Nuclear Factor 1 Transcription factors Transcription Factors - metabolism Transformation Tumors
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