Metformin exhibits preventive and therapeutic efficacy against experimental cystic echinococcosis

Metformin (Met) is an anti-hyperglycemic and potential anti-cancer agent which may exert its anti-proliferative effects via the induction of energetic stress. In this study we investigated the in vitro and in vivo efficacy of Met against the larval stage of Echinococcus granulosus. Metformin showed...

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Veröffentlicht in:	PLoS neglected tropical diseases 2017-02, Vol.11 (2), p.e0005370
Hauptverfasser:	Loos, Julia A, Dávila, Valeria A, Rodrígues, Christian R, Petrigh, Romina, Zoppi, Jorge A, Crocenzi, Fernando A, Cumino, Andrea C
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Anthelmintics - administration & dosage Anthelmintics - pharmacology Biology and Life Sciences Chemoprevention - methods Disease Models, Animal Dosage and administration Drug dosages Drug Synergism Drug therapy Echinococcosis Echinococcosis - drug therapy Echinococcosis - prevention & control Echinococcus granulosus - drug effects Funding Health aspects Kinases Larva - drug effects Medicine and Health Sciences Metformin Metformin - administration & dosage Metformin - pharmacology Mice Parasites Properties Research and Analysis Methods Survival Analysis Synergistic effect Treatment Outcome Tropical diseases Zoonoses
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