Unique 5'-P recognition and basis for dG:dGTP misincorporation of ASFV DNA polymerase X

African swine fever virus (ASFV) can cause highly lethal disease in pigs and is becoming a global threat. ASFV DNA Polymerase X (AsfvPolX) is the most distinctive DNA polymerase identified to date; it lacks two DNA-binding domains (the thumb domain and 8-KD domain) conserved in the homologous protei...

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Veröffentlicht in:	PLoS biology 2017-02, Vol.15 (2), p.e1002599
Hauptverfasser:	Chen, Yiqing, Zhang, Jing, Liu, Hehua, Gao, Yanqing, Li, Xuhang, Zheng, Lina, Cui, Ruixue, Yao, Qingqing, Rong, Liang, Li, Jixi, Huang, Zhen, Ma, Jinbiao, Gan, Jianhua
Format:	Artikel
Sprache:	eng
Schlagworte:	African Swine Fever Virus - enzymology Amino Acids - metabolism Base Sequence Binding Sites Biology and life sciences Biophysics Business travel Collaboration Crystallography, X-Ray Data collection Deoxyguanine Nucleotides - metabolism Deoxyribonucleic acid DNA DNA polymerases DNA repair DNA viruses DNA, Viral - chemistry DNA, Viral - metabolism DNA-Directed DNA Polymerase - metabolism Flaviviridae Genetic engineering Genomes Guanosine triphosphatase Health aspects Hogs Kinetics Laboratories Life sciences Mutagenesis Mutant Proteins - chemistry Mutant Proteins - metabolism Physical Sciences Physiology Plant biology Protein Binding Protein Structure, Secondary R&D Research & development Structural Homology, Protein
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