A high-throughput genetic screen identifies previously uncharacterized Borrelia burgdorferi genes important for resistance against reactive oxygen and nitrogen species

Borrelia burgdorferi, the causative agent of Lyme disease in humans, is exposed to reactive oxygen and nitrogen species (ROS and RNS) in both the tick vector and vertebrate reservoir hosts. B. burgdorferi contains a limited repertoire of canonical oxidative stress response genes, suggesting that nov...

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Veröffentlicht in:	PLoS pathogens 2017-02, Vol.13 (2), p.e1006225-e1006225
Hauptverfasser:	Ramsey, Meghan E, Hyde, Jenny A, Medina-Perez, Diana N, Lin, Tao, Gao, Lihui, Lundt, Maureen E, Li, Xin, Norris, Steven J, Skare, Jon T, Hu, Linden T
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arachnids Biology and Life Sciences Borrelia burgdorferi Borrelia burgdorferi - genetics Borrelia burgdorferi - immunology Colleges & universities Disease Models, Animal DNA repair Free radicals Funding Gene mutation Genes Genes, Bacterial - immunology Genetic aspects Genetic engineering Genetic testing Genomes Health aspects Health sciences High-Throughput Nucleotide Sequencing Immunology Ixodidae Laboratories Lyme disease Lyme Disease - immunology Lyme Disease - microbiology Medicine Medicine and Health Sciences Methods Mice Mice, Inbred C57BL Molecular biology Nitric oxide Oxygen Pathogenesis Pathology Polymerase Chain Reaction Proteins Ratios Reactive Nitrogen Species - metabolism Reactive Oxygen Species - metabolism Research and Analysis Methods
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