Beyond the MHC: A canine model of dermatomyositis shows a complex pattern of genetic risk involving novel loci

Juvenile dermatomyositis (JDM) is a chronic inflammatory myopathy and vasculopathy driven by genetic and environmental influences. Here, we investigated the genetic underpinnings of an analogous, spontaneous disease of dogs also termed dermatomyositis (DMS). As in JDM, we observed a significant asso...

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Veröffentlicht in:	PLoS genetics 2017-02, Vol.13 (2), p.e1006604-e1006604
Hauptverfasser:	Evans, Jacquelyn M, Noorai, Rooksana E, Tsai, Kate L, Starr-Moss, Alison N, Hill, Cody M, Anderson, Kendall J, Famula, Thomas R, Clark, Leigh Anne
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - genetics Age Analysis Animals Biology and Life Sciences Breeding Chromosomes Dermatomyositis Dermatomyositis - epidemiology Dermatomyositis - genetics Dermatomyositis - veterinary Disease Disease Models, Animal Dog Diseases - epidemiology Dog Diseases - genetics Dogs Epidemiology Exoribonucleases - genetics Funding Genetic aspects Genetic Association Studies Genetic Predisposition to Disease Genetics Genome-Wide Association Study Genomes Genomics Haplotypes Health aspects Histocompatibility Antigens Class I - genetics Homozygote Major histocompatibility complex Medicine and Health Sciences Polymorphism, Genetic - genetics Polymorphism, Single Nucleotide Probability Risk Factors
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