A numerical investigation of intrathecal isobaric drug dispersion within the cervical subarachnoid space

Intrathecal drug and gene vector delivery is a procedure to release a solute within the cerebrospinal fluid. This procedure is currently used in clinical practice and shows promise for treatment of several central nervous system pathologies. However, intrathecal delivery protocols and systems are no...

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Veröffentlicht in:	PloS one 2017-03, Vol.12 (3), p.e0173680-e0173680
Hauptverfasser:	Haga, Per Thomas, Pizzichelli, Giulia, Mortensen, Mikael, Kuchta, Miroslav, Pahlavian, Soroush Heidari, Sinibaldi, Edoardo, Martin, Bryn A, Mardal, Kent-Andre
Format:	Artikel
Sprache:	eng
Schlagworte:	Anatomy Biology and Life Sciences Brain research Catheters Central nervous system Cerebrospinal fluid Cervical Vertebrae Computer simulation Dispersion Drug delivery systems Flow rates Flow velocity Gene therapy Health aspects Humans Injection Injections Laboratories Ligaments Mathematical models Mathematics Medical instruments Medical screening Medicine and Health Sciences Meninges Neurosurgery Numerical analysis Numerical models Numerical simulations Pain Physical Sciences Research and Analysis Methods Spinal cord Spine (cervical) Studies Subarachnoid space Subarachnoid Space - drug effects Three dimensional models
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