Implantable porous gelatin microspheres sustained release of bFGF and improved its neuroprotective effect on rats after spinal cord injury

In this study, porous gelatin microspheres (GMSs) were constructed to improve the neuroprotective effect of basic fibroblast growth factor (bFGF) on spinal cord injury. GMSs were prepared by a W/O emulsion template, followed by cross-linking, washing and drying. The particle sizes and surface porosi...

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Veröffentlicht in:	PloS one 2017-03, Vol.12 (3), p.e0173814-e0173814
Hauptverfasser:	Lan, Li, Tian, Fu-Rong, ZhuGe, De-Li, ZhuGe, Qi-Chuan, Shen, Bi-Xin, Jin, Bing-Hui, Huang, Jian-Ping, Wu, Ming-Ze, Fan, Lu-Xin, Zhao, Ying-Zheng, Xu, He-Lin
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Animal experimentation Animals Apoptosis Biology and Life Sciences Care and treatment Controlled release Crosslinking Dosage and administration Drug delivery systems Drying Encapsulation Experiments Fibroblast growth factor Fibroblast growth factor 2 Fibroblast Growth Factor 2 - administration & dosage Fibroblast growth factors Fibroblasts Gelatin Gelatin - administration & dosage Gelatin capsules Growth factors Health aspects Hospitals Immunohistochemistry Implantation Infiltration Injury prevention Laboratory animals Leukocytes Medical research Medicine and Health Sciences Microscopy Microspheres Neurological disorders Neuroprotection Neuroprotective Agents - administration & dosage Pathology Pharmaceutical sciences Physical Sciences Porosity Proteins Rats Rats, Sprague-Dawley Research and Analysis Methods Rodents Spinal cord Spinal cord injuries Spinal Cord Injuries - physiopathology Spinal cord injury Sustained release
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