Depletion of NEAT1 lncRNA attenuates nucleolar stress by releasing sequestered P54nrb and PSF to facilitate c-Myc translation

Altered expression of NEAT1, the architectural long non-coding RNA (lncRNA) of nuclear paraspeckles, has been reported during tumorigenesis, as well as under various cellular stress conditions. Here we report that the depletion of NEAT1 lncRNA alleviates nucleolar stress during RNAP I inhibition thr...

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Veröffentlicht in:	PloS one 2017-03, Vol.12 (3), p.e0173494
Hauptverfasser:	Shen, Wen, Liang, Xue-Hai, Sun, Hong, De Hoyos, Cheryl L, Crooke, Stanley T
Format:	Artikel
Sprache:	eng
Schlagworte:	Antisense oligonucleotides Apoptosis Biology and life sciences c-Myc protein Cell Line, Tumor Cell proliferation Depletion DNA-Binding Proteins Fibrillarin Gene expression Genes, myc Humans Immunoglobulins Inhibition Medical research Messenger RNA Metabolism mRNA Myc protein Non-coding RNA Nuclear Matrix-Associated Proteins - metabolism Nucleoli Octamer Transcription Factors - metabolism Pharmaceuticals Prostate cancer Protein Biosynthesis Proteins PTB-Associated Splicing Factor - metabolism Regulators Research and analysis methods Ribonucleic acid Ribosomal DNA Ribosomal proteins RNA RNA, Long Noncoding - physiology RNA, Messenger - genetics RNA, Ribosomal - genetics RNA-Binding Proteins - metabolism Stem cells Stress Stress (Physiology) Stresses Translation Translation (Genetics) Tumorigenesis Zebrafish
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