Interactions within the MHC contribute to the genetic architecture of celiac disease

Interaction analysis of GWAS can detect signal that would be ignored by single variant analysis, yet few robust interactions in humans have been detected. Recent work has highlighted interactions in the MHC region between known HLA risk haplotypes for various autoimmune diseases. To better understan...

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Veröffentlicht in:	PloS one 2017-03, Vol.12 (3), p.e0172826-e0172826
Hauptverfasser:	Goudey, Benjamin, Abraham, Gad, Kikianty, Eder, Wang, Qiao, Rawlinson, Dave, Shi, Fan, Haviv, Izhak, Stern, Linda, Kowalczyk, Adam, Inouye, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Architecture Area Under Curve Autoimmune diseases Biology and Life Sciences Case-Control Studies Celiac disease Celiac Disease - genetics Celiac Disease - immunology Celiac Disease - pathology Diabetes Disease Epidemiology Genes Genetic aspects Genetics Genome-wide association studies Genome-Wide Association Study Genomes Genomics Gynecology Haplotypes Health aspects Health risks Histocompatibility antigen HLA Humans Linkage Disequilibrium Lymphoma Lymphoma, Non-Hodgkin - genetics Major histocompatibility complex Major Histocompatibility Complex - genetics Medicine and Health Sciences Menopause Non-Hodgkin's lymphoma Obstetrics Polymorphism, Single Nucleotide Population (statistical) Proteins - genetics Risk ROC Curve Single-nucleotide polymorphism Studies Success Support Vector Machine
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