Family-based association study of DRD4 gene in methylphenidate-responded Attention Deficit/Hyperactivity Disorder

The 48-basepair (48-bp) variable number tandem repeat (VNTR) polymorphism in exon 3 of the dopamine receptor D4 gene (DRD4) is implicated in the etiology of attention-deficit/ hyperactivity disorder (ADHD). In particular, ADHD in European-ancestry population is associated with an increased prevalenc...

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Veröffentlicht in:	PloS one 2017-03, Vol.12 (3), p.e0173748-e0173748
Hauptverfasser:	Leung, Patrick Wing-Leung, Chan, Janice Ka Yan, Chen, Lu Hua, Lee, Chi Chiu, Hung, Se Fong, Ho, Ting Pong, Tang, Chun Pan, Moyzis, Robert K, Swanson, James M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Alleles Asian Continental Ancestry Group - genetics Attention Deficit Disorder with Hyperactivity - drug therapy Attention Deficit Disorder with Hyperactivity - genetics Attention deficit hyperactivity disorder Biology and Life Sciences Child Children Collaboration Development and progression Diabetes DNA nucleotidylexotransferase Dopamine Dopamine D4 receptors Dopamine receptors Drugs Etiology Exons Family Female Gene Frequency Gene polymorphism Genes Genetic aspects Genetic polymorphisms Genomes Haplotypes Humans Hyperactivity Male Medicine and Health Sciences Methylphenidate Methylphenidate - pharmacology Minisatellite Repeats Minority & ethnic groups Parents Pediatrics People and Places Physical Sciences Physiological aspects Polymorphism Polymorphism, Genetic Population Population genetics Population studies Predictions Psychiatry Receptors, Dopamine D4 - genetics Research and Analysis Methods Risk analysis Studies
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