PA28 modulates antigen processing and viral replication during coxsackievirus B3 infection

The function of the proteasome is modulated at the level of subunit expression and by association with its regulatory complexes. During coxsackievirus B3 (CVB3) myocarditis, IFN-induced formation of immunoproteasomes (ip) is known to be critical for regulating immune modulating molecules. The functi...

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Veröffentlicht in:	PloS one 2017-03, Vol.12 (3), p.e0173259-e0173259
Hauptverfasser:	Respondek, Dorota, Voss, Martin, Kühlewindt, Ina, Klingel, Karin, Krüger, Elke, Beling, Antje
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigen Presentation Antigen processing Antigens Autoantigens - immunology Biology and Life Sciences Cardiomyocytes Coxsackievirus infections Coxsackievirus Infections - immunology Coxsackievirus Infections - metabolism Coxsackievirus Infections - virology Coxsackieviruses Cytokines Enterovirus Enterovirus B, Human - immunology Epitopes Female Genetic aspects Health aspects Heart Heart diseases Homeostasis Infections Interferon Laboratory animals Major histocompatibility complex Medicine and Health Sciences Mice Mice, Inbred C57BL Mice, Knockout Myocarditis Myocarditis - immunology Myocarditis - metabolism Myocarditis - virology Oxidative stress Peptides Physiology Picornaviridae Proteasome Endopeptidase Complex - immunology Proteasome Endopeptidase Complex - metabolism Proteasome Endopeptidase Complex - physiology Proteasomes Proteins Replication Research and analysis methods Stem cells Studies TLR3 protein Toll-like receptors Ubiquitin-proteasome system Virus Replication γ-Interferon
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