Placental hormone profiles as predictors of preterm birth in twin pregnancy: A prospective cohort study

The objective of the study was to analyse placental hormone profiles in twin pregnancies to determine if they could be used to predict preterm birth. Progesterone, estradiol, estriol and corticotropin-releasing hormone were measured using competitive immunoassay and radioimmunoassay in serum and sal...

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Veröffentlicht in:	PloS one 2017-03, Vol.12 (3), p.e0173732-e0173732
Hauptverfasser:	Lim, Hui, Powell, Sioned, Mcnamara, Helen C, Howie, A Forbes, Doust, Ann, Bowman, Maria E, Smith, Roger, Norman, Jane E, Stock, Sarah J
Format:	Artikel
Sprache:	eng
Schlagworte:	17β-Estradiol Adolescent Adult Biology and Life Sciences Biomarkers Biomarkers - blood Birth Childbirth & labor Cohort analysis Consent Corticotropin Corticotropin-releasing hormone Corticotropin-Releasing Hormone - blood Estradiol - blood Estriol - blood Female Gestation Gestational Age Health aspects Hormones Humans Immunoassay Infant, Newborn Medical research Medicine and Health Sciences Mortality Obstetric Labor, Premature - blood Obstetric Labor, Premature - diagnosis Obstetric Labor, Premature - prevention & control Physical Sciences Placenta Placental hormones Placental Hormones - blood Predictive Value of Tests Pregnancy Pregnancy Trimester, Second Pregnancy, Twin Premature birth Progesterone Progesterone - blood Prospective Studies Radioimmunoassay Reproductive health Saliva Sex hormones Steroids Systematic review Vital statistics Womens health Young Adult
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Zusammenfassung:	The objective of the study was to analyse placental hormone profiles in twin pregnancies to determine if they could be used to predict preterm birth. Progesterone, estradiol, estriol and corticotropin-releasing hormone were measured using competitive immunoassay and radioimmunoassay in serum and saliva samples of 98 women with twin pregnancies,at 3 or more gestational timepoints. Hormone profiles throughout gestation were compared between very preterm (
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0173732