Therapeutic hypothermia increases the risk of cardiac arrhythmia for perinatal hypoxic ischaemic encephalopathy: A meta-analysis
To determine whether therapeutic hypothermia after hypoxic ischaemic encephalopathy (HIE) in neonates increases the risk of cardiac arrhythmia during intervention. A meta-analysis was conducted using a fixed-effect model. Risk ratios, risk differences, and 95% confidence intervals, were measured. St...
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| Veröffentlicht in: | PloS one 2017-03, Vol.12 (3), p.e0173006-e0173006 |
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| creator | Zhang, Wei Lu, Meizhu Zhang, Chenlong Zhang, Ruwen Ou, Xiaofeng Zhou, Jianju Li, Yan Kang, Yan |
| description | To determine whether therapeutic hypothermia after hypoxic ischaemic encephalopathy (HIE) in neonates increases the risk of cardiac arrhythmia during intervention.
A meta-analysis was conducted using a fixed-effect model. Risk ratios, risk differences, and 95% confidence intervals, were measured.
Studies identified from the Cochrane Central Register of Controlled Trials, MEDLINE, EMBASE, Google Scholar, previous reviews, and abstracts from onset to August, 2016.
Reports that compared therapeutic hypothermia with normal care for neonates with HIE and that included data on safety or cardiac arrhythmia, which is of interest to patients and clinicians, were selected.
We found seven trials, encompassing 1322 infants that included information on safety or cardiac arrhythmia during intervention. Therapeutic hypothermia considerably increased the combined rate of cardiac arrhythmia in the seven trials (risk ratio 2.42, 95% confidence interval 1.23 to 4.76. p = 0.01; risk difference 0.02, 95% CI 0.01 to 0.04) during intervention.
In infants with hypoxic ischaemic encephalopathy, therapeutic hypothermia is associated with a consistent increase in cardiac arrhythmia during intervention. |
| doi_str_mv | 10.1371/journal.pone.0173006 |
| format | Article |
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A meta-analysis was conducted using a fixed-effect model. Risk ratios, risk differences, and 95% confidence intervals, were measured.
Studies identified from the Cochrane Central Register of Controlled Trials, MEDLINE, EMBASE, Google Scholar, previous reviews, and abstracts from onset to August, 2016.
Reports that compared therapeutic hypothermia with normal care for neonates with HIE and that included data on safety or cardiac arrhythmia, which is of interest to patients and clinicians, were selected.
We found seven trials, encompassing 1322 infants that included information on safety or cardiac arrhythmia during intervention. Therapeutic hypothermia considerably increased the combined rate of cardiac arrhythmia in the seven trials (risk ratio 2.42, 95% confidence interval 1.23 to 4.76. p = 0.01; risk difference 0.02, 95% CI 0.01 to 0.04) during intervention.
In infants with hypoxic ischaemic encephalopathy, therapeutic hypothermia is associated with a consistent increase in cardiac arrhythmia during intervention.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0173006</identifier><identifier>PMID: 28273115</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Arrhythmia ; Arrhythmias, Cardiac - etiology ; Arrhythmias, Cardiac - physiopathology ; Biology and Life Sciences ; Body temperature regulation ; Cardiac arrhythmia ; Care and treatment ; Clinical trials ; Confidence intervals ; Cooling ; Critical care ; Encephalopathy ; Health aspects ; Heart diseases ; Heart rate ; Humans ; Hypothermia ; Hypothermia, Induced - methods ; Hypoxia ; Hypoxia-Ischemia, Brain - complications ; Hypoxia-Ischemia, Brain - therapy ; Infant ; Infant, Newborn ; Infants ; Intervention ; Medicine ; Medicine and Health Sciences ; Meta-analysis ; Neonatal diseases ; Neonates ; Newborn babies ; Odds Ratio ; Pediatrics ; People and Places ; Physical Sciences ; Randomized Controlled Trials as Topic ; Research and Analysis Methods ; Risk ; Risk factors ; Safety ; Scientific papers ; Studies ; Systematic review</subject><ispartof>PloS one, 2017-03, Vol.12 (3), p.e0173006-e0173006</ispartof><rights>COPYRIGHT 2017 Public Library of Science</rights><rights>2017 Zhang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2017 Zhang et al 2017 Zhang et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c725t-5e34036dfc5fb4057d9377802304f8ad4173b620b9b00eedc8bd604a8897199d3</citedby><cites>FETCH-LOGICAL-c725t-5e34036dfc5fb4057d9377802304f8ad4173b620b9b00eedc8bd604a8897199d3</cites><orcidid>0000-0002-9372-8134</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342232/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342232/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2100,2926,23864,27922,27923,53789,53791,79370,79371</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28273115$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Lazzeri, Chiara</contributor><creatorcontrib>Zhang, Wei</creatorcontrib><creatorcontrib>Lu, Meizhu</creatorcontrib><creatorcontrib>Zhang, Chenlong</creatorcontrib><creatorcontrib>Zhang, Ruwen</creatorcontrib><creatorcontrib>Ou, Xiaofeng</creatorcontrib><creatorcontrib>Zhou, Jianju</creatorcontrib><creatorcontrib>Li, Yan</creatorcontrib><creatorcontrib>Kang, Yan</creatorcontrib><title>Therapeutic hypothermia increases the risk of cardiac arrhythmia for perinatal hypoxic ischaemic encephalopathy: A meta-analysis</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>To determine whether therapeutic hypothermia after hypoxic ischaemic encephalopathy (HIE) in neonates increases the risk of cardiac arrhythmia during intervention.
A meta-analysis was conducted using a fixed-effect model. Risk ratios, risk differences, and 95% confidence intervals, were measured.
Studies identified from the Cochrane Central Register of Controlled Trials, MEDLINE, EMBASE, Google Scholar, previous reviews, and abstracts from onset to August, 2016.
Reports that compared therapeutic hypothermia with normal care for neonates with HIE and that included data on safety or cardiac arrhythmia, which is of interest to patients and clinicians, were selected.
We found seven trials, encompassing 1322 infants that included information on safety or cardiac arrhythmia during intervention. Therapeutic hypothermia considerably increased the combined rate of cardiac arrhythmia in the seven trials (risk ratio 2.42, 95% confidence interval 1.23 to 4.76. p = 0.01; risk difference 0.02, 95% CI 0.01 to 0.04) during intervention.
In infants with hypoxic ischaemic encephalopathy, therapeutic hypothermia is associated with a consistent increase in cardiac arrhythmia during intervention.</description><subject>Arrhythmia</subject><subject>Arrhythmias, Cardiac - etiology</subject><subject>Arrhythmias, Cardiac - physiopathology</subject><subject>Biology and Life Sciences</subject><subject>Body temperature regulation</subject><subject>Cardiac arrhythmia</subject><subject>Care and treatment</subject><subject>Clinical trials</subject><subject>Confidence intervals</subject><subject>Cooling</subject><subject>Critical care</subject><subject>Encephalopathy</subject><subject>Health aspects</subject><subject>Heart diseases</subject><subject>Heart rate</subject><subject>Humans</subject><subject>Hypothermia</subject><subject>Hypothermia, Induced - methods</subject><subject>Hypoxia</subject><subject>Hypoxia-Ischemia, Brain - complications</subject><subject>Hypoxia-Ischemia, Brain - therapy</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Infants</subject><subject>Intervention</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Meta-analysis</subject><subject>Neonatal diseases</subject><subject>Neonates</subject><subject>Newborn babies</subject><subject>Odds Ratio</subject><subject>Pediatrics</subject><subject>People and Places</subject><subject>Physical Sciences</subject><subject>Randomized Controlled Trials as Topic</subject><subject>Research and Analysis Methods</subject><subject>Risk</subject><subject>Risk factors</subject><subject>Safety</subject><subject>Scientific papers</subject><subject>Studies</subject><subject>Systematic 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Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Wei</au><au>Lu, Meizhu</au><au>Zhang, Chenlong</au><au>Zhang, Ruwen</au><au>Ou, Xiaofeng</au><au>Zhou, Jianju</au><au>Li, Yan</au><au>Kang, Yan</au><au>Lazzeri, Chiara</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Therapeutic hypothermia increases the risk of cardiac arrhythmia for perinatal hypoxic ischaemic encephalopathy: A meta-analysis</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2017-03-08</date><risdate>2017</risdate><volume>12</volume><issue>3</issue><spage>e0173006</spage><epage>e0173006</epage><pages>e0173006-e0173006</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>To determine whether therapeutic hypothermia after hypoxic ischaemic encephalopathy (HIE) in neonates increases the risk of cardiac arrhythmia during intervention.
A meta-analysis was conducted using a fixed-effect model. Risk ratios, risk differences, and 95% confidence intervals, were measured.
Studies identified from the Cochrane Central Register of Controlled Trials, MEDLINE, EMBASE, Google Scholar, previous reviews, and abstracts from onset to August, 2016.
Reports that compared therapeutic hypothermia with normal care for neonates with HIE and that included data on safety or cardiac arrhythmia, which is of interest to patients and clinicians, were selected.
We found seven trials, encompassing 1322 infants that included information on safety or cardiac arrhythmia during intervention. Therapeutic hypothermia considerably increased the combined rate of cardiac arrhythmia in the seven trials (risk ratio 2.42, 95% confidence interval 1.23 to 4.76. p = 0.01; risk difference 0.02, 95% CI 0.01 to 0.04) during intervention.
In infants with hypoxic ischaemic encephalopathy, therapeutic hypothermia is associated with a consistent increase in cardiac arrhythmia during intervention.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>28273115</pmid><doi>10.1371/journal.pone.0173006</doi><orcidid>https://orcid.org/0000-0002-9372-8134</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS); EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Arrhythmia Arrhythmias, Cardiac - etiology Arrhythmias, Cardiac - physiopathology Biology and Life Sciences Body temperature regulation Cardiac arrhythmia Care and treatment Clinical trials Confidence intervals Cooling Critical care Encephalopathy Health aspects Heart diseases Heart rate Humans Hypothermia Hypothermia, Induced - methods Hypoxia Hypoxia-Ischemia, Brain - complications Hypoxia-Ischemia, Brain - therapy Infant Infant, Newborn Infants Intervention Medicine Medicine and Health Sciences Meta-analysis Neonatal diseases Neonates Newborn babies Odds Ratio Pediatrics People and Places Physical Sciences Randomized Controlled Trials as Topic Research and Analysis Methods Risk Risk factors Safety Scientific papers Studies Systematic review |
| title | Therapeutic hypothermia increases the risk of cardiac arrhythmia for perinatal hypoxic ischaemic encephalopathy: A meta-analysis |
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