MDR-TB treatment as prevention: The projected population-level impact of expanded treatment for multidrug-resistant tuberculosis

In 2013, approximately 480,000 people developed active multidrug-resistant tuberculosis (MDR-TB), while only 97,000 started MDR-TB treatment. We sought to estimate the impact of improving access to MDR-TB diagnosis and treatment, under multiple diagnostic algorithm and treatment regimen scenarios, o...

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Veröffentlicht in:	PloS one 2017-03, Vol.12 (3), p.e0172748-e0172748
Hauptverfasser:	Kendall, Emily A, Azman, Andrew S, Cobelens, Frank G, Dowdy, David W
Format:	Artikel
Sprache:	eng
Schlagworte:	Antitubercular Agents - therapeutic use Bayes Theorem Bayesian analysis Biology and Life Sciences Calibration Care and treatment Clinical outcomes Computer simulation Diagnosis Diagnostic systems Disease transmission Drug resistance Epidemics Epidemiology Humans Incidence Infectious diseases Medical diagnosis Medical screening Medicine and Health Sciences Microbial drug resistance Multidrug resistance Multidrug resistant organisms Mycobacterium Mycobacterium tuberculosis Ordinary differential equations People and Places Prevention Preventive Health Services - methods Primary Prevention Public health Systematic review Tuberculosis Tuberculosis, Multidrug-Resistant - drug therapy Tuberculosis, Multidrug-Resistant - epidemiology Tuberculosis, Multidrug-Resistant - prevention & control Tuberculosis, Multidrug-Resistant - transmission Uncertainty
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