Melanoma cells undergo aggressive coalescence in a 3D Matrigel model that is repressed by anti-CD44

Using unique computer-assisted 3D reconstruction software, it was previously demonstrated that tumorigenic cell lines derived from breast tumors, when seeded in a 3D Matrigel model, grew as clonal aggregates which, after approximately 100 hours, underwent coalescence mediated by specialized cells, e...

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Veröffentlicht in:	PloS one 2017-03, Vol.12 (3), p.e0173400-e0173400
Hauptverfasser:	Wessels, Deborah, Lusche, Daniel F, Voss, Edward, Kuhl, Spencer, Buchele, Emma C, Klemme, Michael R, Russell, Kanoe B, Ambrose, Joseph, Soll, Benjamin A, Bossler, Aaron, Milhem, Mohammed, Goldman, Charles, Soll, David R
Format:	Artikel
Sprache:	eng
Schlagworte:	Aggregates Antibodies, Monoclonal - pharmacology Biology Biology and Life Sciences Biomarkers Biotechnology Breast Breast cancer Cancer cells CD29 antigen CD44 antigen Cell Adhesion Cell Line Cell migration Cell surface Cell Tracking Coalescence Coalescing Collagen Commonality Computer programs Dosage and administration Drug Combinations Forming Genetic aspects Humans Hyaluronan Receptors - metabolism Integrin beta1 - metabolism Laminin Medicine and Health Sciences Melanocytes Melanocytes - metabolism Melanoma Melanoma - metabolism Melanoma - pathology Metastasis Microscopy Monoclonal antibodies Phenotype Proteoglycans Research and Analysis Methods Spheroids, Cellular Studies Three dimensional models Tumor Cells, Cultured Tumorigenesis Tumors
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