Simvastatin and atorvastatin reduce the mechanical properties of tendon constructs in vitro and introduce catabolic changes in the gene expression pattern

Treatment with lipid-lowering drugs, statins, is common all over the world. Lately, the occurrence of spontaneous tendon ruptures or tendinosis have suggested a negative influence of statins upon tendon tissue. But how statins might influence tendons is not clear. In the present study, we investigat...

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Veröffentlicht in:	PloS one 2017-03, Vol.12 (3), p.e0172797-e0172797
Hauptverfasser:	Eliasson, Pernilla, Svensson, Rene B, Giannopoulos, Antonis, Eismark, Christian, Kjær, Michael, Schjerling, Peter, Heinemeier, Katja M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Atorvastatin Atorvastatin - pharmacology Biology and Life Sciences Bone surgery Cell culture Cell cycle Cell growth Cell proliferation Cell Proliferation - drug effects Cells, Cultured Collagen Collagen (type I) Collagen - genetics Collagen - metabolism Collagenase 3 Dosage and administration Drugs Energy Metabolism - drug effects Extracellular matrix Fibroblasts Fibroblasts - drug effects Fibroblasts - metabolism Gene expression Gene Expression Regulation - drug effects Hospitals Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology Interstitial collagenase Knee Ligaments Matrix metalloproteinase Matrix Metalloproteinases - genetics Matrix Metalloproteinases - metabolism Mechanical Phenomena - drug effects Mechanical properties Mechanical tests Medicine Medicine and Health Sciences Orthopedics Pain Research and analysis methods Simvastatin Simvastatin - pharmacology Sports medicine Statins Stiffness Studies Tendon Injuries - genetics Tendon Injuries - metabolism Tendon Injuries - physiopathology Tendons Tendons - drug effects Tendons - physiology Three dimensional models Tissue culture Tissue inhibitor of metalloproteinase 1 Tissue Inhibitor of Metalloproteinase-1 - genetics Tissue Inhibitor of Metalloproteinase-1 - metabolism Young Adult
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