Vitreous advanced glycation endproducts and α-dicarbonyls in retinal detachment patients with type 2 diabetes mellitus and non-diabetic controls

Advanced glycation endproducts (AGEs) and their precursors α-dicarbonyls are implicated in the progression of diabetic retinopathy. The purpose of this study was to assess AGEs and α-dicarbonyls in the vitreous of patients with type 2 diabetes mellitus (T2DM) with early stages or absence of diabetic...

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Veröffentlicht in:	PloS one 2017-03, Vol.12 (3), p.e0173379-e0173379
Hauptverfasser:	Fokkens, Bernardina T, Mulder, Douwe J, Schalkwijk, Casper G, Scheijen, Jean L, Smit, Andries J, Los, Leonoor I
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Advanced glycosylation end products Age Aged Aged, 80 and over Arginine - analogs & derivatives Arginine - metabolism Biology and Life Sciences Biomarkers Carboxymethyllysine Case-Control Studies Chromatography Deoxyglucose - analogs & derivatives Deoxyglucose - metabolism Detaching Detachment Diabetes Diabetes mellitus Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - complications Diabetic retinopathy Diabetic Retinopathy - etiology Diabetic Retinopathy - metabolism Female Glomerular filtration rate Glucose Glycation End Products, Advanced - metabolism Glycosylation Hemoglobin High performance liquid chromatography Humans Implantation Inflammatory diseases Internal medicine Kidney diseases Laboratories Liquid chromatography Lysine Lysine - analogs & derivatives Lysine - metabolism Male Medicine Medicine and Health Sciences Metabolism Middle Aged Oxidative stress Patients Pentosidine Physical Sciences Proteins Pyruvaldehyde Retina Retinal Detachment - etiology Retinal Detachment - metabolism Retinopathy Skin Smoking
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