Dendritic stratification differs among retinal OFF bipolar cell types in the absence of rod photoreceptors
Retinal OFF bipolar cells show distinct connectivity patterns with photoreceptors in the wild-type mouse retina. Some types are cone-specific while others penetrate further through the outer plexiform layer (OPL) to contact rods in addition to cones. To explore dendritic stratification of OFF bipola...
Gespeichert in:
| Veröffentlicht in: | PloS one 2017-03, Vol.12 (3), p.e0173455-e0173455 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | e0173455 |
|---|---|
| container_issue | 3 |
| container_start_page | e0173455 |
| container_title | PloS one |
| container_volume | 12 |
| creator | Puller, Christian Arbogast, Patrick Keeley, Patrick W Reese, Benjamin E Haverkamp, Silke |
| description | Retinal OFF bipolar cells show distinct connectivity patterns with photoreceptors in the wild-type mouse retina. Some types are cone-specific while others penetrate further through the outer plexiform layer (OPL) to contact rods in addition to cones. To explore dendritic stratification of OFF bipolar cells in the absence of rods, we made use of the 'cone-full' Nrl-/- mouse retina in which all photoreceptor precursor cells commit to a cone fate including those which would have become rods in wild-type retinas. The dendritic distribution of OFF bipolar cell types was investigated by confocal and electron microscopic imaging of immunolabeled tissue sections. The cells' dendrites formed basal contacts with cone terminals and expressed the corresponding glutamate receptor subunits at those sites, indicating putative synapses. All of the four analyzed cell populations showed distinctive patterns of vertical dendritic invasion through the OPL. This disparate behavior of dendritic extension in an environment containing only cone terminals demonstrates type-dependent specificity for dendritic outgrowth in OFF bipolar cells: rod terminals are not required for inducing dendritic extension into distal areas of the OPL. |
| doi_str_mv | 10.1371/journal.pone.0173455 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_1874150040</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A483896342</galeid><doaj_id>oai_doaj_org_article_80c9645579df42baac3ebe479aed3ed6</doaj_id><sourcerecordid>A483896342</sourcerecordid><originalsourceid>FETCH-LOGICAL-c725t-c6cde9861c92c6179116d71e16c7e2fbc0c45964333681e5aae0b322d52a0c103</originalsourceid><addsrcrecordid>eNqNk12L1DAUhoso7rr6D0QDgujFjPlOeyMsq6MDCwN-3YY0PZ3J0Glq0or77013ustW9mIpJCF9zntO3uRk2UuCl4Qp8mHvh9CaZtn5FpaYKMaFeJSdkoLRhaSYPb6zPsmexbjHWLBcyqfZCc2pULzAp9n-E7RVcL2zKPbB9K52No2-RZWrawgRmYNvtyhA71I2tFmtUOk635iALDQN6q86iMi1qN8BMmWE1gLyNQq-Qt3O9z6AhS5N8Xn2pDZNhBfTfJb9XH3-cfF1cbn5sr44v1xYRUW_sNJWUOSS2IJaSVRBiKwUASKtAlqXFlsuCskZYzInIIwBXDJKK0ENtgSzs-z1UbdrfNSTTVGTXHEiMOYjsT4SlTd73QV3MOFKe-P09YYPW21CsqQBnWObcgmhiqrmtDTGMiiBq8JAxaCSSevjlG0oD1BZaJONzUx0_qd1O731f7RI9dOcJYF3k0DwvweIvT64OFprWvDDdd0qpxzj_CEo51xJNqJv_kPvN2Kitiad1bW1TyXaUVSf85zlhWScJmp5D5W-Cg7OpudXu7Q_C3g_C0hMD3_7rRli1Ovv3x7Obn7N2bd32B2Ypt9F3wzje41zkB9BG3yMAerb-yBYj91z44Yeu0dP3ZPCXt29y9ugm3Zh_wATyRTZ</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1874150040</pqid></control><display><type>article</type><title>Dendritic stratification differs among retinal OFF bipolar cell types in the absence of rod photoreceptors</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><source>Public Library of Science (PLoS)</source><creator>Puller, Christian ; Arbogast, Patrick ; Keeley, Patrick W ; Reese, Benjamin E ; Haverkamp, Silke</creator><creatorcontrib>Puller, Christian ; Arbogast, Patrick ; Keeley, Patrick W ; Reese, Benjamin E ; Haverkamp, Silke</creatorcontrib><description>Retinal OFF bipolar cells show distinct connectivity patterns with photoreceptors in the wild-type mouse retina. Some types are cone-specific while others penetrate further through the outer plexiform layer (OPL) to contact rods in addition to cones. To explore dendritic stratification of OFF bipolar cells in the absence of rods, we made use of the 'cone-full' Nrl-/- mouse retina in which all photoreceptor precursor cells commit to a cone fate including those which would have become rods in wild-type retinas. The dendritic distribution of OFF bipolar cell types was investigated by confocal and electron microscopic imaging of immunolabeled tissue sections. The cells' dendrites formed basal contacts with cone terminals and expressed the corresponding glutamate receptor subunits at those sites, indicating putative synapses. All of the four analyzed cell populations showed distinctive patterns of vertical dendritic invasion through the OPL. This disparate behavior of dendritic extension in an environment containing only cone terminals demonstrates type-dependent specificity for dendritic outgrowth in OFF bipolar cells: rod terminals are not required for inducing dendritic extension into distal areas of the OPL.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0173455</identifier><identifier>PMID: 28257490</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Animals ; Basic-Leucine Zipper Transcription Factors - genetics ; Biology and Life Sciences ; Bipolar cells ; Brain research ; Cones ; Dendrites ; Dendritic cells ; Dendritic Cells - metabolism ; Dendritic Cells - ultrastructure ; Disease Models, Animal ; Eye Proteins - genetics ; Glutamate receptors ; Glutamic Acid - genetics ; Glutamic Acid - metabolism ; Glutamic acid receptors ; Humans ; Immunoglobulins ; Medicine and Health Sciences ; Mice ; Mice, Knockout ; Microscopy ; Microscopy, Electron ; Morphology ; Neurosciences ; Photoreception ; Photoreceptors ; Research and Analysis Methods ; Retina ; Retinal Bipolar Cells - metabolism ; Retinal Bipolar Cells - ultrastructure ; Retinal Photoreceptor Cell Outer Segment - ultrastructure ; Retinal Rod Photoreceptor Cells - metabolism ; Retinal Rod Photoreceptor Cells - ultrastructure ; Rodents ; Rods ; Social Sciences ; Synapses ; Synapses - genetics ; Synapses - metabolism ; Synapses - ultrastructure ; Terminals</subject><ispartof>PloS one, 2017-03, Vol.12 (3), p.e0173455-e0173455</ispartof><rights>COPYRIGHT 2017 Public Library of Science</rights><rights>2017 Puller et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2017 Puller et al 2017 Puller et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c725t-c6cde9861c92c6179116d71e16c7e2fbc0c45964333681e5aae0b322d52a0c103</citedby><cites>FETCH-LOGICAL-c725t-c6cde9861c92c6179116d71e16c7e2fbc0c45964333681e5aae0b322d52a0c103</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5336283/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5336283/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28257490$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Puller, Christian</creatorcontrib><creatorcontrib>Arbogast, Patrick</creatorcontrib><creatorcontrib>Keeley, Patrick W</creatorcontrib><creatorcontrib>Reese, Benjamin E</creatorcontrib><creatorcontrib>Haverkamp, Silke</creatorcontrib><title>Dendritic stratification differs among retinal OFF bipolar cell types in the absence of rod photoreceptors</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Retinal OFF bipolar cells show distinct connectivity patterns with photoreceptors in the wild-type mouse retina. Some types are cone-specific while others penetrate further through the outer plexiform layer (OPL) to contact rods in addition to cones. To explore dendritic stratification of OFF bipolar cells in the absence of rods, we made use of the 'cone-full' Nrl-/- mouse retina in which all photoreceptor precursor cells commit to a cone fate including those which would have become rods in wild-type retinas. The dendritic distribution of OFF bipolar cell types was investigated by confocal and electron microscopic imaging of immunolabeled tissue sections. The cells' dendrites formed basal contacts with cone terminals and expressed the corresponding glutamate receptor subunits at those sites, indicating putative synapses. All of the four analyzed cell populations showed distinctive patterns of vertical dendritic invasion through the OPL. This disparate behavior of dendritic extension in an environment containing only cone terminals demonstrates type-dependent specificity for dendritic outgrowth in OFF bipolar cells: rod terminals are not required for inducing dendritic extension into distal areas of the OPL.</description><subject>Animals</subject><subject>Basic-Leucine Zipper Transcription Factors - genetics</subject><subject>Biology and Life Sciences</subject><subject>Bipolar cells</subject><subject>Brain research</subject><subject>Cones</subject><subject>Dendrites</subject><subject>Dendritic cells</subject><subject>Dendritic Cells - metabolism</subject><subject>Dendritic Cells - ultrastructure</subject><subject>Disease Models, Animal</subject><subject>Eye Proteins - genetics</subject><subject>Glutamate receptors</subject><subject>Glutamic Acid - genetics</subject><subject>Glutamic Acid - metabolism</subject><subject>Glutamic acid receptors</subject><subject>Humans</subject><subject>Immunoglobulins</subject><subject>Medicine and Health Sciences</subject><subject>Mice</subject><subject>Mice, Knockout</subject><subject>Microscopy</subject><subject>Microscopy, Electron</subject><subject>Morphology</subject><subject>Neurosciences</subject><subject>Photoreception</subject><subject>Photoreceptors</subject><subject>Research and Analysis Methods</subject><subject>Retina</subject><subject>Retinal Bipolar Cells - metabolism</subject><subject>Retinal Bipolar Cells - ultrastructure</subject><subject>Retinal Photoreceptor Cell Outer Segment - ultrastructure</subject><subject>Retinal Rod Photoreceptor Cells - metabolism</subject><subject>Retinal Rod Photoreceptor Cells - ultrastructure</subject><subject>Rodents</subject><subject>Rods</subject><subject>Social Sciences</subject><subject>Synapses</subject><subject>Synapses - genetics</subject><subject>Synapses - metabolism</subject><subject>Synapses - ultrastructure</subject><subject>Terminals</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk12L1DAUhoso7rr6D0QDgujFjPlOeyMsq6MDCwN-3YY0PZ3J0Glq0or77013ustW9mIpJCF9zntO3uRk2UuCl4Qp8mHvh9CaZtn5FpaYKMaFeJSdkoLRhaSYPb6zPsmexbjHWLBcyqfZCc2pULzAp9n-E7RVcL2zKPbB9K52No2-RZWrawgRmYNvtyhA71I2tFmtUOk635iALDQN6q86iMi1qN8BMmWE1gLyNQq-Qt3O9z6AhS5N8Xn2pDZNhBfTfJb9XH3-cfF1cbn5sr44v1xYRUW_sNJWUOSS2IJaSVRBiKwUASKtAlqXFlsuCskZYzInIIwBXDJKK0ENtgSzs-z1UbdrfNSTTVGTXHEiMOYjsT4SlTd73QV3MOFKe-P09YYPW21CsqQBnWObcgmhiqrmtDTGMiiBq8JAxaCSSevjlG0oD1BZaJONzUx0_qd1O731f7RI9dOcJYF3k0DwvweIvT64OFprWvDDdd0qpxzj_CEo51xJNqJv_kPvN2Kitiad1bW1TyXaUVSf85zlhWScJmp5D5W-Cg7OpudXu7Q_C3g_C0hMD3_7rRli1Ovv3x7Obn7N2bd32B2Ypt9F3wzje41zkB9BG3yMAerb-yBYj91z44Yeu0dP3ZPCXt29y9ugm3Zh_wATyRTZ</recordid><startdate>20170303</startdate><enddate>20170303</enddate><creator>Puller, Christian</creator><creator>Arbogast, Patrick</creator><creator>Keeley, Patrick W</creator><creator>Reese, Benjamin E</creator><creator>Haverkamp, Silke</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20170303</creationdate><title>Dendritic stratification differs among retinal OFF bipolar cell types in the absence of rod photoreceptors</title><author>Puller, Christian ; Arbogast, Patrick ; Keeley, Patrick W ; Reese, Benjamin E ; Haverkamp, Silke</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c725t-c6cde9861c92c6179116d71e16c7e2fbc0c45964333681e5aae0b322d52a0c103</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Animals</topic><topic>Basic-Leucine Zipper Transcription Factors - genetics</topic><topic>Biology and Life Sciences</topic><topic>Bipolar cells</topic><topic>Brain research</topic><topic>Cones</topic><topic>Dendrites</topic><topic>Dendritic cells</topic><topic>Dendritic Cells - metabolism</topic><topic>Dendritic Cells - ultrastructure</topic><topic>Disease Models, Animal</topic><topic>Eye Proteins - genetics</topic><topic>Glutamate receptors</topic><topic>Glutamic Acid - genetics</topic><topic>Glutamic Acid - metabolism</topic><topic>Glutamic acid receptors</topic><topic>Humans</topic><topic>Immunoglobulins</topic><topic>Medicine and Health Sciences</topic><topic>Mice</topic><topic>Mice, Knockout</topic><topic>Microscopy</topic><topic>Microscopy, Electron</topic><topic>Morphology</topic><topic>Neurosciences</topic><topic>Photoreception</topic><topic>Photoreceptors</topic><topic>Research and Analysis Methods</topic><topic>Retina</topic><topic>Retinal Bipolar Cells - metabolism</topic><topic>Retinal Bipolar Cells - ultrastructure</topic><topic>Retinal Photoreceptor Cell Outer Segment - ultrastructure</topic><topic>Retinal Rod Photoreceptor Cells - metabolism</topic><topic>Retinal Rod Photoreceptor Cells - ultrastructure</topic><topic>Rodents</topic><topic>Rods</topic><topic>Social Sciences</topic><topic>Synapses</topic><topic>Synapses - genetics</topic><topic>Synapses - metabolism</topic><topic>Synapses - ultrastructure</topic><topic>Terminals</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Puller, Christian</creatorcontrib><creatorcontrib>Arbogast, Patrick</creatorcontrib><creatorcontrib>Keeley, Patrick W</creatorcontrib><creatorcontrib>Reese, Benjamin E</creatorcontrib><creatorcontrib>Haverkamp, Silke</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Puller, Christian</au><au>Arbogast, Patrick</au><au>Keeley, Patrick W</au><au>Reese, Benjamin E</au><au>Haverkamp, Silke</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dendritic stratification differs among retinal OFF bipolar cell types in the absence of rod photoreceptors</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2017-03-03</date><risdate>2017</risdate><volume>12</volume><issue>3</issue><spage>e0173455</spage><epage>e0173455</epage><pages>e0173455-e0173455</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Retinal OFF bipolar cells show distinct connectivity patterns with photoreceptors in the wild-type mouse retina. Some types are cone-specific while others penetrate further through the outer plexiform layer (OPL) to contact rods in addition to cones. To explore dendritic stratification of OFF bipolar cells in the absence of rods, we made use of the 'cone-full' Nrl-/- mouse retina in which all photoreceptor precursor cells commit to a cone fate including those which would have become rods in wild-type retinas. The dendritic distribution of OFF bipolar cell types was investigated by confocal and electron microscopic imaging of immunolabeled tissue sections. The cells' dendrites formed basal contacts with cone terminals and expressed the corresponding glutamate receptor subunits at those sites, indicating putative synapses. All of the four analyzed cell populations showed distinctive patterns of vertical dendritic invasion through the OPL. This disparate behavior of dendritic extension in an environment containing only cone terminals demonstrates type-dependent specificity for dendritic outgrowth in OFF bipolar cells: rod terminals are not required for inducing dendritic extension into distal areas of the OPL.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>28257490</pmid><doi>10.1371/journal.pone.0173455</doi><tpages>e0173455</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2017-03, Vol.12 (3), p.e0173455-e0173455 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1874150040 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Animals Basic-Leucine Zipper Transcription Factors - genetics Biology and Life Sciences Bipolar cells Brain research Cones Dendrites Dendritic cells Dendritic Cells - metabolism Dendritic Cells - ultrastructure Disease Models, Animal Eye Proteins - genetics Glutamate receptors Glutamic Acid - genetics Glutamic Acid - metabolism Glutamic acid receptors Humans Immunoglobulins Medicine and Health Sciences Mice Mice, Knockout Microscopy Microscopy, Electron Morphology Neurosciences Photoreception Photoreceptors Research and Analysis Methods Retina Retinal Bipolar Cells - metabolism Retinal Bipolar Cells - ultrastructure Retinal Photoreceptor Cell Outer Segment - ultrastructure Retinal Rod Photoreceptor Cells - metabolism Retinal Rod Photoreceptor Cells - ultrastructure Rodents Rods Social Sciences Synapses Synapses - genetics Synapses - metabolism Synapses - ultrastructure Terminals |
| title | Dendritic stratification differs among retinal OFF bipolar cell types in the absence of rod photoreceptors |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-08T15%3A02%3A00IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Dendritic%20stratification%20differs%20among%20retinal%20OFF%20bipolar%20cell%20types%20in%20the%20absence%20of%20rod%20photoreceptors&rft.jtitle=PloS%20one&rft.au=Puller,%20Christian&rft.date=2017-03-03&rft.volume=12&rft.issue=3&rft.spage=e0173455&rft.epage=e0173455&rft.pages=e0173455-e0173455&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0173455&rft_dat=%3Cgale_plos_%3EA483896342%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1874150040&rft_id=info:pmid/28257490&rft_galeid=A483896342&rft_doaj_id=oai_doaj_org_article_80c9645579df42baac3ebe479aed3ed6&rfr_iscdi=true |