Anti-Inflammatory Properties of the Enaminone E121 in the Dextran Sulfate Sodium (DSS) Colitis Model

Enaminones are synthetic compounds with an established role in the prevention of various forms of seizures. Recent evidence suggests potent anti-tussive, bronchodilation and anti-inflammatory properties. Pre-treatment with particularly E121 compound resulted in a decrease in leukocyte recruitment in...

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Veröffentlicht in:	PloS one 2016-12, Vol.11 (12), p.e0168567-e0168567
Hauptverfasser:	Khajah, Maitham A, Ananthalakshmi, Kethireddy V, Edafiogho, Ivan
Format:	Artikel
Sprache:	eng
Schlagworte:	Aniline Compounds - pharmacology Animals Annexin V Anti-inflammatory agents Anti-Inflammatory Agents - pharmacology Apoptosis Assaying Asthma Biology and Life Sciences Bronchodilation Bronchodilators Care and treatment Cell proliferation Cell survival Cell Survival - drug effects Cell Survival - immunology Chemotaxis Chemotaxis - drug effects Colitis Colitis - chemically induced Colitis - drug therapy Colitis - immunology Colon Complications and side effects Cyclohexanecarboxylic Acids - pharmacology Cytokines Cytometry Dextran Dextran sulfate Dextran Sulfate - toxicity Dextrans Dosage and administration Flow cytometry Genetically modified mice Immunofluorescence Inflammation Inflammatory bowel disease Inflammatory bowel diseases Interleukin Interleukin 2 Interleukin-2 - immunology Intestine Kinases Leukocytes Medicine and Health Sciences Mice Mice, Inbred BALB C Neutrophils - immunology Ovalbumin Oxidation Pathogenesis Phosphorylation Physical Sciences Plasma levels Pretreatment Proteins Risk factors Rodents Seizures Signaling Sodium Sulfate Sulfates Superoxide Superoxides - immunology Tumor necrosis factor-TNF Western blotting White blood cells
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