Prevention of neointimal formation using miRNA-126-containing nanoparticle-conjugated stents in a rabbit model

Despite recent progress with drug-eluting stents, restenosis and thrombosis after endovascular intervention are still major limitations in the treatment of cardiovascular diseases. These problems are possibly caused by inappropriate inhibition of neointimal formation and retardation of re-endothelia...

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Veröffentlicht in:	PloS one 2017-03, Vol.12 (3), p.e0172798-e0172798
Hauptverfasser:	Izuhara, Masayasu, Kuwabara, Yasuhide, Saito, Naritatsu, Yamamoto, Erika, Hakuno, Daihiko, Nakashima, Yasuhiro, Horie, Takahiro, Baba, Osamu, Nishiga, Masataka, Nakao, Tetsushi, Nishino, Tomohiro, Nakazeki, Fumiko, Ide, Yuya, Kimura, Masahiro, Kimura, Takeshi, Ono, Koh
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Angiogenesis Angioplasty Animals Base Sequence Biology and Life Sciences Cardiovascular diseases Cardiovascular system Cell adhesion & migration Cell growth Cell Movement Cell Proliferation Cholesterol Cholesterol - metabolism Double-stranded RNA Drug Carriers - chemistry Drug delivery Drug-Eluting Stents Endothelial cells Endothelium Gene expression Health aspects Heart diseases Human Umbilical Vein Endothelial Cells - cytology Humans Hyperplasia Implants Inhibition Insulin receptor substrate 1 Laboratory animals Lactic Acid - chemistry Medical treatment Medicine Medicine and Health Sciences Membrane permeability MicroRNA MicroRNAs MicroRNAs - chemistry MicroRNAs - genetics MicroRNAs - metabolism miRNA Muscle, Smooth, Vascular - cytology Muscles Nanoparticles Nanoparticles - chemistry Neointima - prevention & control Permeability Physiological aspects Polyglycolic Acid - chemistry Rabbits Research and Analysis Methods Restenosis Ribonucleic acid RNA RNA, Double-Stranded - chemistry RNA, Double-Stranded - genetics RNA, Double-Stranded - metabolism Rodents Smooth muscle Stents Surgical implants Target recognition Thromboembolism Thrombosis Transfection Tumor necrosis factor-TNF
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