Meta-analyses of comparative efficacy of antidepressant medications on peripheral BDNF concentration in patients with depression
Brain derived neurotrophic factor (BDNF) is one of the most important regulatory proteins in the pathophysiology of major depressive disorder (MDD). Increasing numbers of studies have reported the relationship between serum/plasma BDNF and antidepressants (ADs). However, the potential effects of sev...
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| description | Brain derived neurotrophic factor (BDNF) is one of the most important regulatory proteins in the pathophysiology of major depressive disorder (MDD). Increasing numbers of studies have reported the relationship between serum/plasma BDNF and antidepressants (ADs). However, the potential effects of several classes of antidepressants on BDNF concentrations are not well known. Hence, our meta-analyses aims to review the effects of differential antidepressant drugs on peripheral BDNF levels in MDD and make some recommendations for future research.
Electronic databases including PubMed, EMBASE, the Cochrane Library, Web of Science, and PsycINFO were searched from 1980 to June 2016. The change in BDNF levels were compared between baseline and post-antidepressants treatment by use of the standardized mean difference (SMD) with 95% confidence intervals (CIs). All statistical tests were two-sided.
We identified 20 eligible trials of antidepressants treatments for BDNF in MDD. The overall effect size for all drug classes showed that BDNF levels were elevated following a course of antidepressants use. For between-study heterogeneity by stratification analyses, we detect that length of treatment and blood samples are significant effect modifiers for BDNF levels during antidepressants treatment. While both SSRIs and SNRIs could increase the BDNF levels after a period of antidepressant medication treatment, sertraline was superior to other three drugs (venlafaxine, paroxetine or escitalopram) in the early increase of BDNF concentrations with SMD 0.53(95% CI = 0.13-0.93; P = 0.009).
There is some evidence that treatment of antidepressants appears to be effective in the increase of peripheral BDNF levels. More robust evidence indicates that different types of antidepressants appear to induce differential effects on the BDNF levels. Since sertraline makes a particular effect on BDNF concentration within a short amount of time, there is potential value in exploring its relationship with BDNF and its pharmacological mechanism concerning peripheral blood BDNF. Further confirmatory trials are required for both observations. |
| doi_str_mv | 10.1371/journal.pone.0172270 |
| format | Article |
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Electronic databases including PubMed, EMBASE, the Cochrane Library, Web of Science, and PsycINFO were searched from 1980 to June 2016. The change in BDNF levels were compared between baseline and post-antidepressants treatment by use of the standardized mean difference (SMD) with 95% confidence intervals (CIs). All statistical tests were two-sided.
We identified 20 eligible trials of antidepressants treatments for BDNF in MDD. The overall effect size for all drug classes showed that BDNF levels were elevated following a course of antidepressants use. For between-study heterogeneity by stratification analyses, we detect that length of treatment and blood samples are significant effect modifiers for BDNF levels during antidepressants treatment. While both SSRIs and SNRIs could increase the BDNF levels after a period of antidepressant medication treatment, sertraline was superior to other three drugs (venlafaxine, paroxetine or escitalopram) in the early increase of BDNF concentrations with SMD 0.53(95% CI = 0.13-0.93; P = 0.009).
There is some evidence that treatment of antidepressants appears to be effective in the increase of peripheral BDNF levels. More robust evidence indicates that different types of antidepressants appear to induce differential effects on the BDNF levels. Since sertraline makes a particular effect on BDNF concentration within a short amount of time, there is potential value in exploring its relationship with BDNF and its pharmacological mechanism concerning peripheral blood BDNF. Further confirmatory trials are required for both observations.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0172270</identifier><identifier>PMID: 28241064</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Analysis ; Antidepressants ; Antidepressive Agents - therapeutic use ; Biology and Life Sciences ; Blood ; Brain ; Brain-derived neurotrophic factor ; Brain-Derived Neurotrophic Factor - blood ; Care and treatment ; Citalopram ; Citalopram - therapeutic use ; Clinical trials ; Clinical Trials as Topic ; Confidence intervals ; Data Interpretation, Statistical ; Depression (Mood disorder) ; Depression - blood ; Depression - drug therapy ; Dosage and administration ; Drugs ; Heterogeneity ; Humans ; Medical ethics ; Medicine and Health Sciences ; Mental depression ; Meta-analysis ; Paroxetine ; Paroxetine - therapeutic use ; Peripheral blood ; Pharmacology ; Physical Sciences ; Proteins ; Psychological aspects ; Regulatory proteins ; Reproducibility of Results ; Research and Analysis Methods ; Rodents ; Sensitivity and Specificity ; Sertraline ; Sertraline - therapeutic use ; Statistical analysis ; Statistical methods ; Statistical tests ; Studies ; Treatment outcome ; Venlafaxine ; Venlafaxine Hydrochloride - therapeutic use</subject><ispartof>PloS one, 2017-02, Vol.12 (2), p.e0172270-e0172270</ispartof><rights>COPYRIGHT 2017 Public Library of Science</rights><rights>2017 Zhou et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2017 Zhou et al 2017 Zhou et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c725t-5a3b32d91a0ae65cd975f2349c02bc083a926da12a89e704bf25e648f33096023</citedby><cites>FETCH-LOGICAL-c725t-5a3b32d91a0ae65cd975f2349c02bc083a926da12a89e704bf25e648f33096023</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5328267/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5328267/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28241064$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhou, Chanjuan</creatorcontrib><creatorcontrib>Zhong, Jiaju</creatorcontrib><creatorcontrib>Zou, Bin</creatorcontrib><creatorcontrib>Fang, Liang</creatorcontrib><creatorcontrib>Chen, Jianjun</creatorcontrib><creatorcontrib>Deng, Xiao</creatorcontrib><creatorcontrib>Zhang, Lin</creatorcontrib><creatorcontrib>Zhao, Xiang</creatorcontrib><creatorcontrib>Qu, Zehui</creatorcontrib><creatorcontrib>Lei, Yang</creatorcontrib><creatorcontrib>Lei, Ting</creatorcontrib><title>Meta-analyses of comparative efficacy of antidepressant medications on peripheral BDNF concentration in patients with depression</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Brain derived neurotrophic factor (BDNF) is one of the most important regulatory proteins in the pathophysiology of major depressive disorder (MDD). Increasing numbers of studies have reported the relationship between serum/plasma BDNF and antidepressants (ADs). However, the potential effects of several classes of antidepressants on BDNF concentrations are not well known. Hence, our meta-analyses aims to review the effects of differential antidepressant drugs on peripheral BDNF levels in MDD and make some recommendations for future research.
Electronic databases including PubMed, EMBASE, the Cochrane Library, Web of Science, and PsycINFO were searched from 1980 to June 2016. The change in BDNF levels were compared between baseline and post-antidepressants treatment by use of the standardized mean difference (SMD) with 95% confidence intervals (CIs). All statistical tests were two-sided.
We identified 20 eligible trials of antidepressants treatments for BDNF in MDD. The overall effect size for all drug classes showed that BDNF levels were elevated following a course of antidepressants use. For between-study heterogeneity by stratification analyses, we detect that length of treatment and blood samples are significant effect modifiers for BDNF levels during antidepressants treatment. While both SSRIs and SNRIs could increase the BDNF levels after a period of antidepressant medication treatment, sertraline was superior to other three drugs (venlafaxine, paroxetine or escitalopram) in the early increase of BDNF concentrations with SMD 0.53(95% CI = 0.13-0.93; P = 0.009).
There is some evidence that treatment of antidepressants appears to be effective in the increase of peripheral BDNF levels. More robust evidence indicates that different types of antidepressants appear to induce differential effects on the BDNF levels. Since sertraline makes a particular effect on BDNF concentration within a short amount of time, there is potential value in exploring its relationship with BDNF and its pharmacological mechanism concerning peripheral blood BDNF. Further confirmatory trials are required for both observations.</description><subject>Analysis</subject><subject>Antidepressants</subject><subject>Antidepressive Agents - therapeutic use</subject><subject>Biology and Life Sciences</subject><subject>Blood</subject><subject>Brain</subject><subject>Brain-derived neurotrophic factor</subject><subject>Brain-Derived Neurotrophic Factor - blood</subject><subject>Care and treatment</subject><subject>Citalopram</subject><subject>Citalopram - therapeutic use</subject><subject>Clinical trials</subject><subject>Clinical Trials as Topic</subject><subject>Confidence intervals</subject><subject>Data Interpretation, Statistical</subject><subject>Depression (Mood disorder)</subject><subject>Depression - blood</subject><subject>Depression - drug therapy</subject><subject>Dosage and administration</subject><subject>Drugs</subject><subject>Heterogeneity</subject><subject>Humans</subject><subject>Medical ethics</subject><subject>Medicine and Health Sciences</subject><subject>Mental depression</subject><subject>Meta-analysis</subject><subject>Paroxetine</subject><subject>Paroxetine - therapeutic use</subject><subject>Peripheral blood</subject><subject>Pharmacology</subject><subject>Physical Sciences</subject><subject>Proteins</subject><subject>Psychological aspects</subject><subject>Regulatory proteins</subject><subject>Reproducibility of Results</subject><subject>Research and Analysis Methods</subject><subject>Rodents</subject><subject>Sensitivity and Specificity</subject><subject>Sertraline</subject><subject>Sertraline - therapeutic use</subject><subject>Statistical analysis</subject><subject>Statistical methods</subject><subject>Statistical tests</subject><subject>Studies</subject><subject>Treatment outcome</subject><subject>Venlafaxine</subject><subject>Venlafaxine Hydrochloride - therapeutic use</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk01v1DAQhiMEoqXwDxBEQkJw2MUfie1ckEqhsFKhEl9Xy3HGu14lcbCzhb3x03F202qDeqhyyGjmeV87M5kkeYrRHFOO36zdxreqnneuhTnCnBCO7iXHuKBkxgii9w_io-RRCGuEcioYe5gcEUEyjFh2nPz9DL2aqWi0DRBSZ1Ltmk551dsrSMEYq5XeDnnV9raCzkMIMUwbqGKpt66NqjbtwNtuBV7V6bv3X86jS6uh7f2OSG0EYhQTIf1t-1U6GsXa4-SBUXWAJ-P7JPlx_uH72afZxeXHxdnpxUxzkvezXNGSkqrACilgua4KnhtCs0IjUmokqCoIqxQmShTAUVYakgPLhKEUFQwRepI83_t2tQtybF6QWHDKeJ5nLBKLPVE5tZadt43yW-mUlbuE80upfG91DVLxsioEh0ognkEFhQEBUGkoM6NBi-j1djxtUzZDYWhFPTGdVlq7kkt3JXMaZ8N4NHg1Gnj3awOhl40NGupateA2u3tzgXOR0bugRPCc08H1xX_o7Y0YqaWK32pb4-IV9WAqTzNBCWWU4EjNb6HiU0Fj4_jB2JifCF5PBJHp4U-_VJsQ5OLb17uzlz-n7MsDdgWq7lfB1ZvdvzkFsz2ovQvBg7mZB0Zy2Knrbshhp-S4U1H27HCWN6LrJaL_AMPbHnQ</recordid><startdate>20170227</startdate><enddate>20170227</enddate><creator>Zhou, Chanjuan</creator><creator>Zhong, Jiaju</creator><creator>Zou, Bin</creator><creator>Fang, Liang</creator><creator>Chen, Jianjun</creator><creator>Deng, Xiao</creator><creator>Zhang, Lin</creator><creator>Zhao, Xiang</creator><creator>Qu, Zehui</creator><creator>Lei, Yang</creator><creator>Lei, Ting</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20170227</creationdate><title>Meta-analyses of comparative efficacy of antidepressant medications on peripheral BDNF concentration in patients with depression</title><author>Zhou, Chanjuan ; Zhong, Jiaju ; Zou, Bin ; Fang, Liang ; Chen, Jianjun ; Deng, Xiao ; Zhang, Lin ; Zhao, Xiang ; Qu, Zehui ; Lei, Yang ; Lei, Ting</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c725t-5a3b32d91a0ae65cd975f2349c02bc083a926da12a89e704bf25e648f33096023</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Analysis</topic><topic>Antidepressants</topic><topic>Antidepressive Agents - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhou, Chanjuan</au><au>Zhong, Jiaju</au><au>Zou, Bin</au><au>Fang, Liang</au><au>Chen, Jianjun</au><au>Deng, Xiao</au><au>Zhang, Lin</au><au>Zhao, Xiang</au><au>Qu, Zehui</au><au>Lei, Yang</au><au>Lei, Ting</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Meta-analyses of comparative efficacy of antidepressant medications on peripheral BDNF concentration in patients with depression</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2017-02-27</date><risdate>2017</risdate><volume>12</volume><issue>2</issue><spage>e0172270</spage><epage>e0172270</epage><pages>e0172270-e0172270</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Brain derived neurotrophic factor (BDNF) is one of the most important regulatory proteins in the pathophysiology of major depressive disorder (MDD). Increasing numbers of studies have reported the relationship between serum/plasma BDNF and antidepressants (ADs). However, the potential effects of several classes of antidepressants on BDNF concentrations are not well known. Hence, our meta-analyses aims to review the effects of differential antidepressant drugs on peripheral BDNF levels in MDD and make some recommendations for future research.
Electronic databases including PubMed, EMBASE, the Cochrane Library, Web of Science, and PsycINFO were searched from 1980 to June 2016. The change in BDNF levels were compared between baseline and post-antidepressants treatment by use of the standardized mean difference (SMD) with 95% confidence intervals (CIs). All statistical tests were two-sided.
We identified 20 eligible trials of antidepressants treatments for BDNF in MDD. The overall effect size for all drug classes showed that BDNF levels were elevated following a course of antidepressants use. For between-study heterogeneity by stratification analyses, we detect that length of treatment and blood samples are significant effect modifiers for BDNF levels during antidepressants treatment. While both SSRIs and SNRIs could increase the BDNF levels after a period of antidepressant medication treatment, sertraline was superior to other three drugs (venlafaxine, paroxetine or escitalopram) in the early increase of BDNF concentrations with SMD 0.53(95% CI = 0.13-0.93; P = 0.009).
There is some evidence that treatment of antidepressants appears to be effective in the increase of peripheral BDNF levels. More robust evidence indicates that different types of antidepressants appear to induce differential effects on the BDNF levels. Since sertraline makes a particular effect on BDNF concentration within a short amount of time, there is potential value in exploring its relationship with BDNF and its pharmacological mechanism concerning peripheral blood BDNF. Further confirmatory trials are required for both observations.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>28241064</pmid><doi>10.1371/journal.pone.0172270</doi><tpages>e0172270</tpages><oa>free_for_read</oa></addata></record> |
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| language | eng |
| recordid | cdi_plos_journals_1873675546 |
| source | Public Library of Science (PLoS) Journals Open Access; MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Analysis Antidepressants Antidepressive Agents - therapeutic use Biology and Life Sciences Blood Brain Brain-derived neurotrophic factor Brain-Derived Neurotrophic Factor - blood Care and treatment Citalopram Citalopram - therapeutic use Clinical trials Clinical Trials as Topic Confidence intervals Data Interpretation, Statistical Depression (Mood disorder) Depression - blood Depression - drug therapy Dosage and administration Drugs Heterogeneity Humans Medical ethics Medicine and Health Sciences Mental depression Meta-analysis Paroxetine Paroxetine - therapeutic use Peripheral blood Pharmacology Physical Sciences Proteins Psychological aspects Regulatory proteins Reproducibility of Results Research and Analysis Methods Rodents Sensitivity and Specificity Sertraline Sertraline - therapeutic use Statistical analysis Statistical methods Statistical tests Studies Treatment outcome Venlafaxine Venlafaxine Hydrochloride - therapeutic use |
| title | Meta-analyses of comparative efficacy of antidepressant medications on peripheral BDNF concentration in patients with depression |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-05T18%3A20%3A48IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Meta-analyses%20of%20comparative%20efficacy%20of%20antidepressant%20medications%20on%20peripheral%20BDNF%20concentration%20in%20patients%20with%20depression&rft.jtitle=PloS%20one&rft.au=Zhou,%20Chanjuan&rft.date=2017-02-27&rft.volume=12&rft.issue=2&rft.spage=e0172270&rft.epage=e0172270&rft.pages=e0172270-e0172270&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0172270&rft_dat=%3Cgale_plos_%3EA483236321%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1873675546&rft_id=info:pmid/28241064&rft_galeid=A483236321&rft_doaj_id=oai_doaj_org_article_a7bd987ed8074ede9fe8eedceb4fcec8&rfr_iscdi=true |