The platelet-derived growth factor receptor/STAT3 signaling pathway regulates the phenotypic transition of corpus cavernosum smooth muscle in rats

Erectile dysfunction (ED) is a common clinical disease that is difficult to treat. We previously found that hypoxia modulates the phenotype of primary corpus cavernosum smooth muscle cells (CCSMCs) in rats, but the underlying molecular mechanism is still unknown. Platelet-derived growth factor recep...

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Veröffentlicht in:	PloS one 2017-02, Vol.12 (2), p.e0172191-e0172191
Hauptverfasser:	Yan, Jun-Feng, Huang, Wen-Jie, Zhao, Jian-Feng, Fu, Hui-Ying, Zhang, Gao-Yue, Huang, Xiao-Jun, Lv, Bo-Dong
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Actins - metabolism AKT protein Animals Atherosclerosis Becaplermin Biology and Life Sciences Cancer Cell Hypoxia Cells, Cultured Chinese medicine Collagen Collagen Type I - metabolism Desmin Disease Dose-Response Relationship, Drug Elongation Erectile dysfunction Erectile Dysfunction - drug therapy Experiments Genetic aspects Genetic transformation Growth factors Hospitals Hypoxia Impotence Inhibition Kinases Laboratory animals Male Morphology Muscle contraction Muscle Contraction - drug effects Muscle, Smooth - metabolism Muscles Myocytes, Smooth Muscle - metabolism Pathogenesis Penis Penis - metabolism Phenotype Phenotypes Phosphorylation Platelet-derived growth factor Platelet-derived growth factor BB Protein kinase Proteins Proto-Oncogene Proteins c-akt - metabolism Proto-Oncogene Proteins c-sis - pharmacology Rats Rats, Sprague-Dawley Receptors, Platelet-Derived Growth Factor - metabolism Research and Analysis Methods RNA Interference RNA, Small Interfering - metabolism Rodents Signal Transduction Signaling siRNA Smooth muscle Stat3 protein STAT3 Transcription Factor - metabolism Threonine Transcription Transformation Urology Vimentin Vimentin - metabolism
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