Comparative pathology of rhesus macaque and common marmoset animal models with Middle East respiratory syndrome coronavirus

Middle East respiratory syndrome (MERS), which is caused by a newly discovered coronavirus (CoV), has recently emerged. It causes severe viral pneumonia and is associated with a high fatality rate. However, the pathogenesis, comparative pathology and inflammatory cell response of rhesus macaques and...

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Veröffentlicht in:	PloS one 2017-02, Vol.12 (2), p.e0172093-e0172093
Hauptverfasser:	Yu, Pin, Xu, Yanfeng, Deng, Wei, Bao, Linlin, Huang, Lan, Xu, Yuhuan, Yao, Yanfeng, Qin, Chuan
Format:	Artikel
Sprache:	eng
Schlagworte:	Alveoli Analysis Animal models Animal sciences Animals Antigens Biology and life sciences Callithrix Callithrix - physiology Callithrix - virology Comparative analysis Coronaviridae Coronavirus infections Coronavirus Infections - diagnosis Coronavirus Infections - pathology Coronaviruses Degeneration Diagnosis Disease Models, Animal Edema Eosinophils Epithelial cells Hemorrhage Humans Immunohistochemistry In Situ Hybridization Infections Infectious diseases Infiltration Inflammation Laboratory animals Leukocytes (eosinophilic) Leukocytes (neutrophilic) Lung - virology Lungs Macaca mulatta Macaca mulatta - physiology Macaca mulatta - virology Macrophages Macrophages, Alveolar - metabolism Medicine Medicine and Health Sciences Middle East Respiratory Syndrome Coronavirus Pathogenesis Pathological histology Pathology Pneumocytes Pneumonia Pulmonary lesions Research and Analysis Methods Respiratory diseases Ribonucleic acid Risk factors RNA RNA, Viral Rodents Species Specificity Viral infections Virus Replication Viruses Zoology
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