Cholesterol crystals enhance TLR2- and TLR4-mediated pro-inflammatory cytokine responses of monocytes to the proatherogenic oral bacterium Porphyromonas gingivalis

Cholesterol deposits and pro-inflammatory cytokines play an essential role in the pathogenesis of atherosclerosis, a predominant cause of cardiovascular disease (CVD). Epidemiological evidence has linked periodontal disease (PD) with atherosclerotic CVD. Accordingly, viable periodontal pathogens, in...

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Veröffentlicht in:	PloS one 2017-02, Vol.12 (2), p.e0172773-e0172773
Hauptverfasser:	Køllgaard, Tania, Enevold, Christian, Bendtzen, Klaus, Hansen, Peter R, Givskov, Michael, Holmstrup, Palle, Nielsen, Claus H
Format:	Artikel
Sprache:	eng
Schlagworte:	Anaerobic bacteria Animals Arteriosclerosis Atheroembolism Atherosclerosis Atherosclerosis - complications Atherosclerosis - metabolism Atherosclerosis - microbiology Bacteria Biology and Life Sciences Blood & organ donations Cardiovascular disease Cardiovascular diseases Cholesterol Cholesterol - chemistry Cholesterol - metabolism Crystals Cytokines Dentistry E coli Epidemiology Escherichia coli Fibroblasts Glibenclamide Gram-positive bacteria Hospitals Humans Immune system Inflammasomes Inflammasomes - drug effects Inflammasomes - metabolism Inflammation Interleukin 6 Interleukin 8 Interleukin-1beta - metabolism Interleukin-6 - metabolism Interleukin-8 - metabolism Kinases Ligands Lipids Lipopolysaccharides Lipoteichoic acid Medicine and Health Sciences Mice Monocytes Monocytes - metabolism Monocytes - microbiology NLR Family, Pyrin Domain-Containing 3 Protein - antagonists & inhibitors NLR Family, Pyrin Domain-Containing 3 Protein - genetics Odontology Pathogenesis Pathogens Periodontal disease Periodontal Diseases - complications Periodontal Diseases - metabolism Periodontal Diseases - microbiology Periodontics Physical Sciences Plaque, Atherosclerotic - metabolism Plaque, Atherosclerotic - microbiology Plaques Porphyromonas gingivalis Porphyromonas gingivalis - metabolism Porphyromonas gingivalis - pathogenicity Proteins Rheumatology Signal transduction Staphylococcus aureus Staphylococcus aureus - chemistry Staphylococcus aureus - pathogenicity Stimulation Synergism Thyroid gland TLR2 protein TLR4 protein Toll-Like Receptor 2 - administration & dosage Toll-Like Receptor 2 - agonists Toll-Like Receptor 2 - metabolism Toll-Like Receptor 4 - administration & dosage Toll-Like Receptor 4 - agonists Toll-Like Receptor 4 - metabolism Toll-like receptors Tumor Necrosis Factor-alpha - metabolism Tumor necrosis factor-TNF Tumor necrosis factor-α
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