Malignant infarction of the middle cerebral artery in a porcine model. A pilot study

Interspecies variability and poor clinical translation from rodent studies indicate that large gyrencephalic animal stroke models are urgently needed. We present a proof-of-principle study describing an alternative animal model of malignant infarction of the middle cerebral artery (MCA) in the commo...

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Veröffentlicht in:	PloS one 2017-02, Vol.12 (2), p.e0172637-e0172637
Hauptverfasser:	Arikan, Fuat, Martínez-Valverde, Tamara, Sánchez-Guerrero, Ángela, Campos, Mireia, Esteves, Marielle, Gandara, Dario, Torné, Ramon, Castro, Lidia, Dalmau, Antoni, Tibau, Joan, Sahuquillo, Juan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Biology and Life Sciences Blood Brain Brain - blood supply Brain - metabolism Brain - pathology Brain research Breeding of animals Cerebral arteries Cerebral blood flow Cerebral infarction Chlorides Disease Models, Animal Edema Feasibility studies Female Gene Expression Genetically modified animals Glucose - metabolism Glycerol Glycerol - metabolism Hogs Hypoxia Immunohistochemistry Infarction Infarction, Middle Cerebral Artery - diagnosis Infarction, Middle Cerebral Artery - genetics Infarction, Middle Cerebral Artery - metabolism Infarction, Middle Cerebral Artery - pathology Ischemia Lactic acid Lactic Acid - metabolism Medical research Medicine and Health Sciences Metabolism Microdialysis Middle Cerebral Artery - metabolism Middle Cerebral Artery - pathology Neuroprotection Neurosciences Neurosurgery NMR Nuclear magnetic resonance Occlusion Oximetry Oxygen Oxygen - metabolism Partial Pressure Pigs Potassium Potassium - metabolism Pyruvic acid Pyruvic Acid - metabolism Research and Analysis Methods Risk factors Rodents Stroke Studies Sulfonylurea Sulfonylurea Receptors - genetics Sulfonylurea Receptors - metabolism Surgery Swine Territory Transient receptor potential proteins Triphenyltetrazolium chloride TRPM Cation Channels - genetics TRPM Cation Channels - metabolism Veins & arteries
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