RhoA promotes epidermal stem cell proliferation via PKN1-cyclin D1 signaling

Epidermal stem cells (ESCs) play a critical role in wound healing, but the mechanism underlying ESC proliferation is not well defined. Here, we explore the effects of RhoA on ESC proliferation and the possible underlying mechanism. Human ESCs were enriched by rapid adhesion to collagen IV. RhoA(+/+)...

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Veröffentlicht in:	PloS one 2017-02, Vol.12 (2), p.e0172613-e0172613
Hauptverfasser:	Wang, Fan, Zhan, Rixing, Chen, Liang, Dai, Xia, Wang, Wenping, Guo, Rui, Li, Xiaoge, Li, Zhe, Wang, Liang, Huang, Shupeng, Shen, Jie, Li, Shirong, Cao, Chuan
Format:	Artikel
Sprache:	eng
Schlagworte:	15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid - pharmacology ADP Ribose Transferases - pharmacology Animals Biology and Life Sciences Botulinum Toxins - pharmacology Burns - physiopathology Burns - therapy Carbazoles - pharmacology Cell adhesion & migration Cell proliferation Cell Proliferation - drug effects Cells, Cultured Collagen (type IV) Cyclin D1 Cyclin D1 - biosynthesis Cyclin D1 - genetics Cyclin D1 - physiology D1 protein Deoxyribonucleic acid DNA DNA biosynthesis DNA Replication - drug effects Epidermal Cells Epidermal growth factor Epithelial Cells - cytology Epithelial Cells - metabolism Gene expression Health aspects Humans In vivo methods and tests Indole Alkaloids - pharmacology Kinases Male Medicine and Health Sciences Mice Mice, Inbred C57BL Mutation, Missense Plasmids Plastic surgery Primary Cell Culture Protein Kinase C - antagonists & inhibitors Protein Kinase C - genetics Protein Kinase C - physiology Random Allocation Research and Analysis Methods rho GTP-Binding Proteins - agonists rho GTP-Binding Proteins - antagonists & inhibitors rhoA GTP-Binding Protein - deficiency rhoA GTP-Binding Protein - genetics rhoA GTP-Binding Protein - physiology RhoA protein RNA Interference RNA, Small Interfering Signal Transduction - physiology Signaling siRNA Stem cells Stem Cells - cytology Stem Cells - metabolism Synthesis Transfection Wound healing Wound Healing - physiology
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