Morphological study of tooth development in podoplanin-deficient mice
Podoplanin is a mucin-type highly O-glycosylated glycoprotein identified in several somatyic cells: podocytes, alveolar epithelial cells, lymphatic endothelial cells, lymph node stromal fibroblastic reticular cells, osteocytes, odontoblasts, mesothelial cells, glia cells, and others. It has been rep...
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| Veröffentlicht in: | PloS one 2017-02, Vol.12 (2), p.e0171912-e0171912 |
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| creator | Takara, Kenyo Maruo, Naoki Oka, Kyoko Kaji, Chiaki Hatakeyama, Yuji Sawa, Naruhiko Kato, Yukinari Yamashita, Junro Kojima, Hiroshi Sawa, Yoshihiko |
| description | Podoplanin is a mucin-type highly O-glycosylated glycoprotein identified in several somatyic cells: podocytes, alveolar epithelial cells, lymphatic endothelial cells, lymph node stromal fibroblastic reticular cells, osteocytes, odontoblasts, mesothelial cells, glia cells, and others. It has been reported that podoplanin-RhoA interaction induces cytoskeleton relaxation and cell process stretching in fibroblastic cells and osteocytes, and that podoplanin plays a critical role in type I alveolar cell differentiation. It appears that podoplanin plays a number of different roles in contributing to cell functioning and growth by signaling. However, little is known about the functions of podoplanin in the somatic cells of the adult organism because an absence of podoplanin is lethal at birth by the respiratory failure. In this report, we investigated the tooth germ development in podoplanin-knockout mice, and the dentin formation in podoplanin-conditional knockout mice having neural crest-derived cells with deficiency in podoplanin by the Wnt1 promoter and enhancer-driven Cre recombinase: Wnt1-Cre;PdpnΔ/Δmice. In the Wnt1-Cre;PdpnΔ/Δmice, the tooth and alveolar bone showed no morphological abnormalities and grow normally, indicating that podoplanin is not critical in the development of the tooth and bone. |
| doi_str_mv | 10.1371/journal.pone.0171912 |
| format | Article |
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It has been reported that podoplanin-RhoA interaction induces cytoskeleton relaxation and cell process stretching in fibroblastic cells and osteocytes, and that podoplanin plays a critical role in type I alveolar cell differentiation. It appears that podoplanin plays a number of different roles in contributing to cell functioning and growth by signaling. However, little is known about the functions of podoplanin in the somatic cells of the adult organism because an absence of podoplanin is lethal at birth by the respiratory failure. In this report, we investigated the tooth germ development in podoplanin-knockout mice, and the dentin formation in podoplanin-conditional knockout mice having neural crest-derived cells with deficiency in podoplanin by the Wnt1 promoter and enhancer-driven Cre recombinase: Wnt1-Cre;PdpnΔ/Δmice. In the Wnt1-Cre;PdpnΔ/Δmice, the tooth and alveolar bone showed no morphological abnormalities and grow normally, indicating that podoplanin is not critical in the development of the tooth and bone.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0171912</identifier><identifier>PMID: 28222099</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Abnormalities ; Alveolar bone ; Analysis ; Animals ; Antigens ; Biocompatibility ; Biology and Life Sciences ; Biomedical materials ; Blood platelets ; Bone and Bones - embryology ; Bone and Bones - metabolism ; Cell differentiation ; Cells, Cultured ; Cloning ; Cre recombinase ; Cytoskeleton ; Dendritic cells ; Dentin ; Dentin - embryology ; Dentin - metabolism ; Endothelial cells ; Epithelial cells ; Gene Knockout Techniques ; Genes, Reporter ; Glycoproteins ; Kidney - embryology ; Kidney - pathology ; Lymph nodes ; Lymphatic system ; Maxillofacial surgery ; Medicine and Health Sciences ; Membrane Glycoproteins - deficiency ; Membrane Glycoproteins - genetics ; Membrane Glycoproteins - physiology ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Mice, Transgenic ; Morphology ; Morphology (Biology) ; Mucin ; Nervous system ; Neural crest ; Neural Crest - metabolism ; Odontoblasts ; Odontogenesis ; Odontogenesis - genetics ; Odontogenesis - physiology ; Organ Specificity ; Osteocytes ; Podocytes - metabolism ; Podocytes - ultrastructure ; Recombinase ; Research and Analysis Methods ; Respiratory System - embryology ; Respiratory System - metabolism ; RhoA protein ; Rodents ; Signaling ; Somatic cells ; Stem cells ; Stress, Mechanical ; Teeth ; Tooth Germ - embryology ; Tooth Germ - metabolism ; Transgenes ; Transgenic animals</subject><ispartof>PloS one, 2017-02, Vol.12 (2), p.e0171912-e0171912</ispartof><rights>COPYRIGHT 2017 Public Library of Science</rights><rights>2017 Takara et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2017 Takara et al 2017 Takara et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c791t-494f9e00af378061dd1244e7f2efe7d086bf2a886780de5579ec28dd157501f23</citedby><cites>FETCH-LOGICAL-c791t-494f9e00af378061dd1244e7f2efe7d086bf2a886780de5579ec28dd157501f23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5319687/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5319687/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28222099$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Kim, Jung-Eun</contributor><creatorcontrib>Takara, Kenyo</creatorcontrib><creatorcontrib>Maruo, Naoki</creatorcontrib><creatorcontrib>Oka, Kyoko</creatorcontrib><creatorcontrib>Kaji, Chiaki</creatorcontrib><creatorcontrib>Hatakeyama, Yuji</creatorcontrib><creatorcontrib>Sawa, Naruhiko</creatorcontrib><creatorcontrib>Kato, Yukinari</creatorcontrib><creatorcontrib>Yamashita, Junro</creatorcontrib><creatorcontrib>Kojima, Hiroshi</creatorcontrib><creatorcontrib>Sawa, Yoshihiko</creatorcontrib><title>Morphological study of tooth development in podoplanin-deficient mice</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Podoplanin is a mucin-type highly O-glycosylated glycoprotein identified in several somatyic cells: podocytes, alveolar epithelial cells, lymphatic endothelial cells, lymph node stromal fibroblastic reticular cells, osteocytes, odontoblasts, mesothelial cells, glia cells, and others. It has been reported that podoplanin-RhoA interaction induces cytoskeleton relaxation and cell process stretching in fibroblastic cells and osteocytes, and that podoplanin plays a critical role in type I alveolar cell differentiation. It appears that podoplanin plays a number of different roles in contributing to cell functioning and growth by signaling. However, little is known about the functions of podoplanin in the somatic cells of the adult organism because an absence of podoplanin is lethal at birth by the respiratory failure. In this report, we investigated the tooth germ development in podoplanin-knockout mice, and the dentin formation in podoplanin-conditional knockout mice having neural crest-derived cells with deficiency in podoplanin by the Wnt1 promoter and enhancer-driven Cre recombinase: Wnt1-Cre;PdpnΔ/Δmice. 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embryology</subject><subject>Kidney - pathology</subject><subject>Lymph nodes</subject><subject>Lymphatic system</subject><subject>Maxillofacial surgery</subject><subject>Medicine and Health Sciences</subject><subject>Membrane Glycoproteins - deficiency</subject><subject>Membrane Glycoproteins - genetics</subject><subject>Membrane Glycoproteins - physiology</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Knockout</subject><subject>Mice, Transgenic</subject><subject>Morphology</subject><subject>Morphology (Biology)</subject><subject>Mucin</subject><subject>Nervous system</subject><subject>Neural crest</subject><subject>Neural Crest - metabolism</subject><subject>Odontoblasts</subject><subject>Odontogenesis</subject><subject>Odontogenesis - genetics</subject><subject>Odontogenesis - physiology</subject><subject>Organ Specificity</subject><subject>Osteocytes</subject><subject>Podocytes - metabolism</subject><subject>Podocytes - ultrastructure</subject><subject>Recombinase</subject><subject>Research and Analysis Methods</subject><subject>Respiratory System - embryology</subject><subject>Respiratory System - metabolism</subject><subject>RhoA protein</subject><subject>Rodents</subject><subject>Signaling</subject><subject>Somatic cells</subject><subject>Stem cells</subject><subject>Stress, Mechanical</subject><subject>Teeth</subject><subject>Tooth Germ - embryology</subject><subject>Tooth Germ - metabolism</subject><subject>Transgenes</subject><subject>Transgenic animals</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk01r3DAQhk1padK0_6C0hkJpD7vVh21Jl0IIabuQEujXVcjSaFeL1nIsOzT_vnLWCeuSQ-yDxeiZV6N3PFn2GqMlpgx_2oaha5RftqGBJcIMC0yeZMdYULKoCKJPD9ZH2YsYtwiVlFfV8-yIcEIIEuI4O_8eunYTfFg7rXwe-8Hc5MHmfQj9JjdwDT60O2j63DV5G0xovWpcszBgnXZjfOc0vMyeWeUjvJq-J9nvL-e_zr4tLi6_rs5OLxaaCdwvClFYAQgpSxlHFTYGk6IAZglYYAbxqrZEcV6lXQNlyQRowhNVshJhS-hJ9nav2_oQ5eRAlJgzVFGKK56I1Z4wQW1l27md6m5kUE7eBkK3lqrrnfYgCdGIM4wNr6Gg2qja8opzZgtVI6jH0z5Ppw31DoxOt-2Un4nOdxq3ketwLUuKRcVZEvgwCXThaoDYy52LGnyyEMJwWzfjlGNcPgZFIhmDUULf_Yc-bMRErVW6q2tsSCXqUVSeFhyL9LCxwuUDVHoNpL6mP8u6FJ8lfJwlJKaHv_1aDTHK1c8fj2cv_8zZ9wfsBpTvNzH4oXehiXOw2IO6CzF2YO_7gZEcB-PODTkOhpwGI6W9OezlfdLdJNB_euwH2g</recordid><startdate>20170221</startdate><enddate>20170221</enddate><creator>Takara, Kenyo</creator><creator>Maruo, Naoki</creator><creator>Oka, Kyoko</creator><creator>Kaji, Chiaki</creator><creator>Hatakeyama, Yuji</creator><creator>Sawa, Naruhiko</creator><creator>Kato, Yukinari</creator><creator>Yamashita, Junro</creator><creator>Kojima, Hiroshi</creator><creator>Sawa, Yoshihiko</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20170221</creationdate><title>Morphological study of tooth development in podoplanin-deficient mice</title><author>Takara, Kenyo ; Maruo, Naoki ; Oka, Kyoko ; Kaji, Chiaki ; Hatakeyama, Yuji ; Sawa, Naruhiko ; Kato, Yukinari ; Yamashita, Junro ; Kojima, Hiroshi ; Sawa, Yoshihiko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c791t-494f9e00af378061dd1244e7f2efe7d086bf2a886780de5579ec28dd157501f23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Abnormalities</topic><topic>Alveolar bone</topic><topic>Analysis</topic><topic>Animals</topic><topic>Antigens</topic><topic>Biocompatibility</topic><topic>Biology and Life Sciences</topic><topic>Biomedical materials</topic><topic>Blood platelets</topic><topic>Bone and Bones - embryology</topic><topic>Bone and Bones - metabolism</topic><topic>Cell differentiation</topic><topic>Cells, Cultured</topic><topic>Cloning</topic><topic>Cre recombinase</topic><topic>Cytoskeleton</topic><topic>Dendritic cells</topic><topic>Dentin</topic><topic>Dentin - embryology</topic><topic>Dentin - metabolism</topic><topic>Endothelial cells</topic><topic>Epithelial cells</topic><topic>Gene Knockout Techniques</topic><topic>Genes, Reporter</topic><topic>Glycoproteins</topic><topic>Kidney - embryology</topic><topic>Kidney - pathology</topic><topic>Lymph nodes</topic><topic>Lymphatic system</topic><topic>Maxillofacial surgery</topic><topic>Medicine and Health Sciences</topic><topic>Membrane Glycoproteins - deficiency</topic><topic>Membrane Glycoproteins - genetics</topic><topic>Membrane Glycoproteins - physiology</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Knockout</topic><topic>Mice, Transgenic</topic><topic>Morphology</topic><topic>Morphology (Biology)</topic><topic>Mucin</topic><topic>Nervous system</topic><topic>Neural crest</topic><topic>Neural Crest - metabolism</topic><topic>Odontoblasts</topic><topic>Odontogenesis</topic><topic>Odontogenesis - genetics</topic><topic>Odontogenesis - physiology</topic><topic>Organ Specificity</topic><topic>Osteocytes</topic><topic>Podocytes - metabolism</topic><topic>Podocytes - ultrastructure</topic><topic>Recombinase</topic><topic>Research and Analysis Methods</topic><topic>Respiratory System - embryology</topic><topic>Respiratory System - metabolism</topic><topic>RhoA protein</topic><topic>Rodents</topic><topic>Signaling</topic><topic>Somatic cells</topic><topic>Stem cells</topic><topic>Stress, Mechanical</topic><topic>Teeth</topic><topic>Tooth Germ - embryology</topic><topic>Tooth Germ - metabolism</topic><topic>Transgenes</topic><topic>Transgenic animals</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Takara, Kenyo</creatorcontrib><creatorcontrib>Maruo, Naoki</creatorcontrib><creatorcontrib>Oka, Kyoko</creatorcontrib><creatorcontrib>Kaji, Chiaki</creatorcontrib><creatorcontrib>Hatakeyama, Yuji</creatorcontrib><creatorcontrib>Sawa, Naruhiko</creatorcontrib><creatorcontrib>Kato, Yukinari</creatorcontrib><creatorcontrib>Yamashita, Junro</creatorcontrib><creatorcontrib>Kojima, Hiroshi</creatorcontrib><creatorcontrib>Sawa, Yoshihiko</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Takara, Kenyo</au><au>Maruo, Naoki</au><au>Oka, Kyoko</au><au>Kaji, Chiaki</au><au>Hatakeyama, Yuji</au><au>Sawa, Naruhiko</au><au>Kato, Yukinari</au><au>Yamashita, Junro</au><au>Kojima, Hiroshi</au><au>Sawa, Yoshihiko</au><au>Kim, Jung-Eun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Morphological study of tooth development in podoplanin-deficient mice</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2017-02-21</date><risdate>2017</risdate><volume>12</volume><issue>2</issue><spage>e0171912</spage><epage>e0171912</epage><pages>e0171912-e0171912</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Podoplanin is a mucin-type highly O-glycosylated glycoprotein identified in several somatyic cells: podocytes, alveolar epithelial cells, lymphatic endothelial cells, lymph node stromal fibroblastic reticular cells, osteocytes, odontoblasts, mesothelial cells, glia cells, and others. It has been reported that podoplanin-RhoA interaction induces cytoskeleton relaxation and cell process stretching in fibroblastic cells and osteocytes, and that podoplanin plays a critical role in type I alveolar cell differentiation. It appears that podoplanin plays a number of different roles in contributing to cell functioning and growth by signaling. However, little is known about the functions of podoplanin in the somatic cells of the adult organism because an absence of podoplanin is lethal at birth by the respiratory failure. In this report, we investigated the tooth germ development in podoplanin-knockout mice, and the dentin formation in podoplanin-conditional knockout mice having neural crest-derived cells with deficiency in podoplanin by the Wnt1 promoter and enhancer-driven Cre recombinase: Wnt1-Cre;PdpnΔ/Δmice. In the Wnt1-Cre;PdpnΔ/Δmice, the tooth and alveolar bone showed no morphological abnormalities and grow normally, indicating that podoplanin is not critical in the development of the tooth and bone.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>28222099</pmid><doi>10.1371/journal.pone.0171912</doi><tpages>e0171912</tpages><oa>free_for_read</oa></addata></record> |
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| recordid | cdi_plos_journals_1870633168 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS); EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Abnormalities Alveolar bone Analysis Animals Antigens Biocompatibility Biology and Life Sciences Biomedical materials Blood platelets Bone and Bones - embryology Bone and Bones - metabolism Cell differentiation Cells, Cultured Cloning Cre recombinase Cytoskeleton Dendritic cells Dentin Dentin - embryology Dentin - metabolism Endothelial cells Epithelial cells Gene Knockout Techniques Genes, Reporter Glycoproteins Kidney - embryology Kidney - pathology Lymph nodes Lymphatic system Maxillofacial surgery Medicine and Health Sciences Membrane Glycoproteins - deficiency Membrane Glycoproteins - genetics Membrane Glycoproteins - physiology Mice Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Morphology Morphology (Biology) Mucin Nervous system Neural crest Neural Crest - metabolism Odontoblasts Odontogenesis Odontogenesis - genetics Odontogenesis - physiology Organ Specificity Osteocytes Podocytes - metabolism Podocytes - ultrastructure Recombinase Research and Analysis Methods Respiratory System - embryology Respiratory System - metabolism RhoA protein Rodents Signaling Somatic cells Stem cells Stress, Mechanical Teeth Tooth Germ - embryology Tooth Germ - metabolism Transgenes Transgenic animals |
| title | Morphological study of tooth development in podoplanin-deficient mice |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T01%3A43%3A00IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Morphological%20study%20of%20tooth%20development%20in%20podoplanin-deficient%20mice&rft.jtitle=PloS%20one&rft.au=Takara,%20Kenyo&rft.date=2017-02-21&rft.volume=12&rft.issue=2&rft.spage=e0171912&rft.epage=e0171912&rft.pages=e0171912-e0171912&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0171912&rft_dat=%3Cgale_plos_%3EA481999977%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1870633168&rft_id=info:pmid/28222099&rft_galeid=A481999977&rft_doaj_id=oai_doaj_org_article_22c08711d8be43cdabf86887f4ab0eb2&rfr_iscdi=true |