A Novel Functional Domain of Tab2 Involved in the Interaction with Estrogen Receptor Alpha in Breast Cancer Cells

Tab2, originally described as a component of the inflammatory pathway, has been implicated in phenomena of gene de-repression in several contexts, due to its ability to interact with the NCoR corepressor. Tab2 interacts also with steroid receptors and dismisses NCoR from antagonist-bound Estrogen an...

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Veröffentlicht in:	PloS one 2016-12, Vol.11 (12), p.e0168639-e0168639
Hauptverfasser:	Reineri, Stefania, Agati, Silvia, Miano, Valentina, Sani, Monica, Berchialla, Paola, Ricci, Laura, Iannello, Andrea, Coscujuela Tarrero, Lucia, Cutrupi, Santina, De Bortoli, Michele
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Amino Acid Motifs Androgen receptors Androgens Biology and Life Sciences Breast cancer Breast carcinoma Breast Neoplasms - drug therapy Breast Neoplasms - genetics Breast Neoplasms - metabolism Cancer Data processing Drug development Drug Resistance, Neoplasm - drug effects Drug Resistance, Neoplasm - genetics Estrogen Estrogen Receptor alpha - genetics Estrogen Receptor alpha - metabolism Estrogen receptors Estrogens Female Genetic aspects Humans Immunoprecipitation In vitro methods and tests Inflammation Kinases MCF-7 Cells Medicine and Health Sciences Mimicry Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Peptides - genetics Peptides - pharmacology Pharmacology Phosphorylation Physical Sciences Physiological aspects Prostate Prostate cancer Protein Domains Proteins Receptors Regulatory sequences Research and Analysis Methods Steroid hormone receptors Tamoxifen Tamoxifen - pharmacology Transcription Tumor cell lines
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