HTLV-1 bZIP Factor Enhances T-Cell Proliferation by Impeding the Suppressive Signaling of Co-inhibitory Receptors

Human T-cell leukemia virus type 1 (HTLV-1) causes adult T-cell leukemia-lymphoma (ATL) and inflammatory diseases. To enhance cell-to-cell transmission of HTLV-1, the virus increases the number of infected cells in vivo. HTLV-1 bZIP factor (HBZ) is constitutively expressed in HTLV-1 infected cells a...

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Veröffentlicht in:	PLoS pathogens 2017-01, Vol.13 (1), p.e1006120-e1006120
Hauptverfasser:	Kinosada, Haruka, Yasunaga, Jun-Ichirou, Shimura, Kazuya, Miyazato, Paola, Onishi, Chiho, Iyoda, Tomonori, Inaba, Kayo, Matsuoka, Masao
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Basic-Leucine Zipper Transcription Factors - genetics Basic-Leucine Zipper Transcription Factors - metabolism Biology and Life Sciences CD3 Complex - metabolism Cell death Cell growth Cell Line, Tumor Cell Proliferation - physiology Development and progression Encephalomyelitis, Autoimmune, Experimental - virology Flow cytometry Funding Genes GRB2 Adaptor Protein - metabolism HTLV-I Infections - transmission HTLV-I Infections - virology Human T-lymphotropic virus 1 - pathogenicity Humans Immunology Inflammatory diseases Jurkat Cells Laboratories Leukemia Life sciences Lymphocyte Activation - immunology Lymphocytes Lymphoma Medical research Medicine and Health Sciences Mice Mice, Inbred C57BL Mice, Transgenic Non-Hodgkin's lymphomas Physiological aspects Physiology Programmed Cell Death 1 Receptor - biosynthesis Programmed Cell Death 1 Receptor - metabolism Protein Tyrosine Phosphatase, Non-Receptor Type 11 - metabolism Proteins - metabolism R&D Receptors, Immunologic - biosynthesis Receptors, Immunologic - metabolism Research & development Research and Analysis Methods Retroviridae Retroviridae Proteins - genetics Retroviridae Proteins - metabolism Rodents T cell receptors T cells T-Lymphocytes - immunology ZAP-70 Protein-Tyrosine Kinase - metabolism
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