Re-wiring of energy metabolism promotes viability during hyperreplication stress in E. coli

Chromosome replication in Escherichia coli is initiated by DnaA. DnaA binds ATP which is essential for formation of a DnaA-oriC nucleoprotein complex that promotes strand opening, helicase loading and replisome assembly. Following initiation, DnaAATP is converted to DnaAADP primarily by the Regulato...

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Veröffentlicht in:	PLoS genetics 2017-01, Vol.13 (1), p.e1006590-e1006590
Hauptverfasser:	Charbon, Godefroid, Campion, Christopher, Chan, Siu Hung Joshua, Bjørn, Louise, Weimann, Allan, da Silva, Luís Cláudio Nascimento, Jensen, Peter Ruhdal, Løbner-Olesen, Anders
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Bacteria Bacterial Proteins - genetics Bacterial Proteins - metabolism Biology Biology and Life Sciences Cell cycle Chromosome replication Chromosomes Colleges & universities Cytochrome Cytochromes - genetics Cytochromes - metabolism Deoxyribonucleic acid DNA DNA Replication DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism E coli Electron Transport Chain Complex Proteins - genetics Electron Transport Chain Complex Proteins - metabolism Energy Metabolism Escherichia coli Escherichia coli - genetics Escherichia coli - metabolism Escherichia coli Proteins - genetics Escherichia coli Proteins - metabolism Funding Genetic aspects Genomics Glycerol Metabolism Mutation Oxidoreductases - genetics Oxidoreductases - metabolism Physical Sciences Physiological aspects Proteins Replication Origin Research and Analysis Methods Stress response Stress, Physiological
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