The association between human endogenous retroviruses and multiple sclerosis: A systematic review and meta-analysis
The interaction between genetic and environmental factors is crucial to multiple sclerosis (MS) pathogenesis. Human Endogenous Retroviruses (HERVs) are endogenous viral elements of the human genome whose expression is associated with MS. To perform a systematic review and meta-analysis and to assess...
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| creator | Morandi, Elena Tanasescu, Radu Tarlinton, Rachael E Constantinescu, Cris S Zhang, Weiya Tench, Christopher Gran, Bruno |
| description | The interaction between genetic and environmental factors is crucial to multiple sclerosis (MS) pathogenesis. Human Endogenous Retroviruses (HERVs) are endogenous viral elements of the human genome whose expression is associated with MS.
To perform a systematic review and meta-analysis and to assess qualitative and quantitative evidence on the expression of HERV families in MS patients.
Medline, Embase and the Cochrane Library were searched for published studies on the association of HERVs and MS. Meta-analysis was performed on the HERV-W family. Odds Ratio (OR) and 95% confidence interval (CI) were calculated for association.
43 reports were extracted (25 related to HERV-W, 13 to HERV-H, 9 to HERV-K, 5 to HRES-1 and 1 to HER-15 family). The analysis showed an association between expression of all HERV families and MS. For HERV-W, adequate data was available for meta-analysis. Results from meta-analyses of HERV-W were OR = 22.66 (95%CI 6.32 to 81.20) from 4 studies investigating MSRV/HERV-W (MS-associated retrovirus) envelope mRNA in peripheral blood mononuclear cells, OR = 44.11 (95%CI 12.95 to 150.30) from 6 studies of MSRV/HERV-W polymerase mRNA in serum/plasma and OR = 6.00 (95%CI 3.35 to 10.74) from 4 studies of MSRV/HERV-W polymerase mRNA in CSF.
This systematic review and meta-analysis shows an association between expression of HERVs, and in particular the HERV-W family, and MS. |
| doi_str_mv | 10.1371/journal.pone.0172415 |
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To perform a systematic review and meta-analysis and to assess qualitative and quantitative evidence on the expression of HERV families in MS patients.
Medline, Embase and the Cochrane Library were searched for published studies on the association of HERVs and MS. Meta-analysis was performed on the HERV-W family. Odds Ratio (OR) and 95% confidence interval (CI) were calculated for association.
43 reports were extracted (25 related to HERV-W, 13 to HERV-H, 9 to HERV-K, 5 to HRES-1 and 1 to HER-15 family). The analysis showed an association between expression of all HERV families and MS. For HERV-W, adequate data was available for meta-analysis. Results from meta-analyses of HERV-W were OR = 22.66 (95%CI 6.32 to 81.20) from 4 studies investigating MSRV/HERV-W (MS-associated retrovirus) envelope mRNA in peripheral blood mononuclear cells, OR = 44.11 (95%CI 12.95 to 150.30) from 6 studies of MSRV/HERV-W polymerase mRNA in serum/plasma and OR = 6.00 (95%CI 3.35 to 10.74) from 4 studies of MSRV/HERV-W polymerase mRNA in CSF.
This systematic review and meta-analysis shows an association between expression of HERVs, and in particular the HERV-W family, and MS.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0172415</identifier><identifier>PMID: 28207850</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Analysis ; Binding sites ; Biology and Life Sciences ; Cerebrospinal fluid ; Confidence intervals ; Endogenous retroviruses ; Endogenous Retroviruses - pathogenicity ; Environmental factors ; Epidemiology ; Gene expression ; Genetic aspects ; Genomes ; Genomics ; Humans ; Leukocytes (mononuclear) ; Medical ethics ; Medicine ; Medicine and Health Sciences ; Meta-analysis ; mRNA ; Multiple sclerosis ; Multiple Sclerosis - virology ; Nervous system ; Neurology ; Neurosciences ; Pathogenesis ; Peripheral blood mononuclear cells ; Physical Sciences ; Proteins ; Qualitative analysis ; Research and Analysis Methods ; Retroviridae ; Retroviruses ; Systematic review ; Viral infections</subject><ispartof>PloS one, 2017-02, Vol.12 (2), p.e0172415</ispartof><rights>COPYRIGHT 2017 Public Library of Science</rights><rights>2017 Morandi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2017 Morandi et al 2017 Morandi et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c684t-ded0550a16ddda049e65ad41f4a17c5007b47fa789d576e0c37cbf721ccfaffe3</citedby><cites>FETCH-LOGICAL-c684t-ded0550a16ddda049e65ad41f4a17c5007b47fa789d576e0c37cbf721ccfaffe3</cites><orcidid>0000-0001-6384-2342</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5313176/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5313176/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79569,79570</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28207850$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Morandi, Elena</creatorcontrib><creatorcontrib>Tanasescu, Radu</creatorcontrib><creatorcontrib>Tarlinton, Rachael E</creatorcontrib><creatorcontrib>Constantinescu, Cris S</creatorcontrib><creatorcontrib>Zhang, Weiya</creatorcontrib><creatorcontrib>Tench, Christopher</creatorcontrib><creatorcontrib>Gran, Bruno</creatorcontrib><title>The association between human endogenous retroviruses and multiple sclerosis: A systematic review and meta-analysis</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>The interaction between genetic and environmental factors is crucial to multiple sclerosis (MS) pathogenesis. Human Endogenous Retroviruses (HERVs) are endogenous viral elements of the human genome whose expression is associated with MS.
To perform a systematic review and meta-analysis and to assess qualitative and quantitative evidence on the expression of HERV families in MS patients.
Medline, Embase and the Cochrane Library were searched for published studies on the association of HERVs and MS. Meta-analysis was performed on the HERV-W family. Odds Ratio (OR) and 95% confidence interval (CI) were calculated for association.
43 reports were extracted (25 related to HERV-W, 13 to HERV-H, 9 to HERV-K, 5 to HRES-1 and 1 to HER-15 family). The analysis showed an association between expression of all HERV families and MS. For HERV-W, adequate data was available for meta-analysis. Results from meta-analyses of HERV-W were OR = 22.66 (95%CI 6.32 to 81.20) from 4 studies investigating MSRV/HERV-W (MS-associated retrovirus) envelope mRNA in peripheral blood mononuclear cells, OR = 44.11 (95%CI 12.95 to 150.30) from 6 studies of MSRV/HERV-W polymerase mRNA in serum/plasma and OR = 6.00 (95%CI 3.35 to 10.74) from 4 studies of MSRV/HERV-W polymerase mRNA in CSF.
This systematic review and meta-analysis shows an association between expression of HERVs, and in particular the HERV-W family, and MS.</description><subject>Analysis</subject><subject>Binding sites</subject><subject>Biology and Life Sciences</subject><subject>Cerebrospinal fluid</subject><subject>Confidence intervals</subject><subject>Endogenous retroviruses</subject><subject>Endogenous Retroviruses - pathogenicity</subject><subject>Environmental factors</subject><subject>Epidemiology</subject><subject>Gene expression</subject><subject>Genetic aspects</subject><subject>Genomes</subject><subject>Genomics</subject><subject>Humans</subject><subject>Leukocytes (mononuclear)</subject><subject>Medical ethics</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Meta-analysis</subject><subject>mRNA</subject><subject>Multiple sclerosis</subject><subject>Multiple Sclerosis - virology</subject><subject>Nervous 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one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Morandi, Elena</au><au>Tanasescu, Radu</au><au>Tarlinton, Rachael E</au><au>Constantinescu, Cris S</au><au>Zhang, Weiya</au><au>Tench, Christopher</au><au>Gran, Bruno</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The association between human endogenous retroviruses and multiple sclerosis: A systematic review and meta-analysis</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2017-02-16</date><risdate>2017</risdate><volume>12</volume><issue>2</issue><spage>e0172415</spage><pages>e0172415-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>The interaction between genetic and environmental factors is crucial to multiple sclerosis (MS) pathogenesis. Human Endogenous Retroviruses (HERVs) are endogenous viral elements of the human genome whose expression is associated with MS.
To perform a systematic review and meta-analysis and to assess qualitative and quantitative evidence on the expression of HERV families in MS patients.
Medline, Embase and the Cochrane Library were searched for published studies on the association of HERVs and MS. Meta-analysis was performed on the HERV-W family. Odds Ratio (OR) and 95% confidence interval (CI) were calculated for association.
43 reports were extracted (25 related to HERV-W, 13 to HERV-H, 9 to HERV-K, 5 to HRES-1 and 1 to HER-15 family). The analysis showed an association between expression of all HERV families and MS. For HERV-W, adequate data was available for meta-analysis. Results from meta-analyses of HERV-W were OR = 22.66 (95%CI 6.32 to 81.20) from 4 studies investigating MSRV/HERV-W (MS-associated retrovirus) envelope mRNA in peripheral blood mononuclear cells, OR = 44.11 (95%CI 12.95 to 150.30) from 6 studies of MSRV/HERV-W polymerase mRNA in serum/plasma and OR = 6.00 (95%CI 3.35 to 10.74) from 4 studies of MSRV/HERV-W polymerase mRNA in CSF.
This systematic review and meta-analysis shows an association between expression of HERVs, and in particular the HERV-W family, and MS.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>28207850</pmid><doi>10.1371/journal.pone.0172415</doi><orcidid>https://orcid.org/0000-0001-6384-2342</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Analysis Binding sites Biology and Life Sciences Cerebrospinal fluid Confidence intervals Endogenous retroviruses Endogenous Retroviruses - pathogenicity Environmental factors Epidemiology Gene expression Genetic aspects Genomes Genomics Humans Leukocytes (mononuclear) Medical ethics Medicine Medicine and Health Sciences Meta-analysis mRNA Multiple sclerosis Multiple Sclerosis - virology Nervous system Neurology Neurosciences Pathogenesis Peripheral blood mononuclear cells Physical Sciences Proteins Qualitative analysis Research and Analysis Methods Retroviridae Retroviruses Systematic review Viral infections |
| title | The association between human endogenous retroviruses and multiple sclerosis: A systematic review and meta-analysis |
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