Role of glycogen synthase kinase-3β and PPAR-γ on epithelial-to-mesenchymal transition in DSS-induced colorectal fibrosis

Intestinal fibrosis is characterized by abnormal production and deposition of extracellular matrix (ECM) proteins by activated myofibroblasts. The main progenitor cells of activated myofibroblasts are the fibroblasts and the epithelial cells, the latter through the epithelial-mesenchymal transition...

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Veröffentlicht in:	PloS one 2017-02, Vol.12 (2), p.e0171093-e0171093
Hauptverfasser:	Di Gregorio, Jacopo, Sferra, Roberta, Speca, Silvia, Vetuschi, Antonella, Dubuquoy, Caroline, Desreumaux, Pierre, Pompili, Simona, Cristiano, Loredana, Gaudio, Eugenio, Flati, Vincenzo, Latella, Giovanni
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biology and Life Sciences Cell adhesion & migration Cells (biology) Cells, Cultured Colitis Colitis - chemically induced Colitis - metabolism Colitis - pathology Collagen (type I) Colon Dextran Sulfate - toxicity Drugs E-cadherin Environmental science Epithelial cells Epithelial-Mesenchymal Transition Extracellular matrix Fibroblasts Fibronectin Fibrosis Fibrosis - chemically induced Fibrosis - metabolism Fibrosis - pathology Glycogen Glycogen synthase kinase 3 Glycogen Synthase Kinase 3 beta - genetics Glycogen Synthase Kinase 3 beta - metabolism Immunofluorescence Immunohistochemistry Inflammation Inflammatory bowel disease Interleukin 13 Intestine Kinases Medicine and Health Sciences Mesenchyme Mice Mice, Inbred C57BL Oral administration Peroxisome proliferator-activated receptors PPAR gamma - genetics PPAR gamma - metabolism Progenitor cells Proteins Rectum - drug effects Rectum - metabolism Rectum - pathology Regulatory proteins Research and Analysis Methods Rodents Signal Transduction Smad3 protein Stem cells Transcription factors Transforming Growth Factor beta - genetics Transforming Growth Factor beta - metabolism β-catenin
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