Prognostic significance of chemotherapy-induced necrosis in osteosarcoma patients receiving pasteurized autografts
Among various reconstruction methods after wide excision for osteosarcoma, pasteurized autograft is often preferred. While the whole area of the tumor can be assessed for chemotherapy-induced necrosis, one of the important prognostic factors, in other reconstructive techniques, only a portion remove...
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| description | Among various reconstruction methods after wide excision for osteosarcoma, pasteurized autograft is often preferred. While the whole area of the tumor can be assessed for chemotherapy-induced necrosis, one of the important prognostic factors, in other reconstructive techniques, only a portion removed from a wide-resection specimen is available when using pasteurized autograft method. The assessment, therefore, may be unreliable. We analyzed the prognostic significance of the chemotherapy-induced necrosis in osteosarcoma patients who underwent reconstruction with pasteurized autografts.
We reviewed the records of osteosarcoma patients who underwent treatment in our institution from 1998 to 2013. Cases of reconstruction with pasteurized autografts were defined as the patient group, and the same number of patients who underwent other reconstruction methods served as controls. Chemotherapy-induced necrosis was evaluated for removed extra-osseous and curetted intramedullary tumor tissues.
A total of 22 patients were identified; the median age was 15.5 years, and there were 12 males. The most common tumor location was the distal femur. The most common histological subtype was osteoblastic. Median size was 8.1 cm. Disease status was stage IIB in 13 patients and IIA in 9. Median follow-up was 76 months. No differences between the patient and control groups were observed in potential prognostic factors, overall survival, metastasis-free survival, or recurrence-free survival. Univariate analyses demonstrated that histological response was a significant prognostic factor for metastasis-free survival and also significant for recurrence-free survival.
Chemotherapy-induced necrosis grading, using only available tumor tissues, could be a prognostic factor for osteosarcoma patients receiving pasteurized autografts for reconstructive surgery. |
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We reviewed the records of osteosarcoma patients who underwent treatment in our institution from 1998 to 2013. Cases of reconstruction with pasteurized autografts were defined as the patient group, and the same number of patients who underwent other reconstruction methods served as controls. Chemotherapy-induced necrosis was evaluated for removed extra-osseous and curetted intramedullary tumor tissues.
A total of 22 patients were identified; the median age was 15.5 years, and there were 12 males. The most common tumor location was the distal femur. The most common histological subtype was osteoblastic. Median size was 8.1 cm. Disease status was stage IIB in 13 patients and IIA in 9. Median follow-up was 76 months. No differences between the patient and control groups were observed in potential prognostic factors, overall survival, metastasis-free survival, or recurrence-free survival. Univariate analyses demonstrated that histological response was a significant prognostic factor for metastasis-free survival and also significant for recurrence-free survival.
Chemotherapy-induced necrosis grading, using only available tumor tissues, could be a prognostic factor for osteosarcoma patients receiving pasteurized autografts for reconstructive surgery.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0172155</identifier><identifier>PMID: 28196121</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Analysis ; Autografts ; Biocompatibility ; Biology and Life Sciences ; Bone cancer ; Bone Transplantation ; Care and treatment ; Chemotherapy ; Child ; Control methods ; Disease-Free Survival ; Drug dosages ; Evaluation ; Female ; Femoral Neoplasms - mortality ; Femoral Neoplasms - pathology ; Femoral Neoplasms - surgery ; Femur ; Gangrene ; Heat ; Hospitals ; Humans ; Male ; Males ; Medical prognosis ; Medicine ; Medicine and Health Sciences ; Metastases ; Metastasis ; Middle Aged ; Necrosis ; Osteoblasts ; Osteonecrosis - etiology ; Osteonecrosis - mortality ; Osteonecrosis - pathology ; Osteosarcoma ; Osteosarcoma - mortality ; Osteosarcoma - pathology ; Osteosarcoma - surgery ; Pasteurization ; Patients ; Physiological aspects ; Plastic surgery ; Prognosis ; Prostheses ; Reconstruction ; Reconstructive surgery ; Retrospective Studies ; Sarcoma ; Skin & tissue grafts ; Studies ; Surgery ; Survival ; Survival Rate ; Tissues ; Tumors ; Young Adult</subject><ispartof>PloS one, 2017-02, Vol.12 (2), p.e0172155-e0172155</ispartof><rights>COPYRIGHT 2017 Public Library of Science</rights><rights>2017 Joo et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2017 Joo et al 2017 Joo et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c725t-b2c31e62f8419d47d497aa58bba0301e94d9e9fb5e4e88c8db9ab1e0ee8fca033</citedby><cites>FETCH-LOGICAL-c725t-b2c31e62f8419d47d497aa58bba0301e94d9e9fb5e4e88c8db9ab1e0ee8fca033</cites><orcidid>0000-0001-8153-8205</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5308815/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5308815/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28196121$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Alonso, Marta M.</contributor><creatorcontrib>Joo, Min Wook</creatorcontrib><creatorcontrib>Kang, Yong Koo</creatorcontrib><creatorcontrib>Yoo, Chang-Young</creatorcontrib><creatorcontrib>Cha, Sung Ho</creatorcontrib><creatorcontrib>Chung, Yang-Guk</creatorcontrib><title>Prognostic significance of chemotherapy-induced necrosis in osteosarcoma patients receiving pasteurized autografts</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Among various reconstruction methods after wide excision for osteosarcoma, pasteurized autograft is often preferred. While the whole area of the tumor can be assessed for chemotherapy-induced necrosis, one of the important prognostic factors, in other reconstructive techniques, only a portion removed from a wide-resection specimen is available when using pasteurized autograft method. The assessment, therefore, may be unreliable. We analyzed the prognostic significance of the chemotherapy-induced necrosis in osteosarcoma patients who underwent reconstruction with pasteurized autografts.
We reviewed the records of osteosarcoma patients who underwent treatment in our institution from 1998 to 2013. Cases of reconstruction with pasteurized autografts were defined as the patient group, and the same number of patients who underwent other reconstruction methods served as controls. Chemotherapy-induced necrosis was evaluated for removed extra-osseous and curetted intramedullary tumor tissues.
A total of 22 patients were identified; the median age was 15.5 years, and there were 12 males. The most common tumor location was the distal femur. The most common histological subtype was osteoblastic. Median size was 8.1 cm. Disease status was stage IIB in 13 patients and IIA in 9. Median follow-up was 76 months. No differences between the patient and control groups were observed in potential prognostic factors, overall survival, metastasis-free survival, or recurrence-free survival. Univariate analyses demonstrated that histological response was a significant prognostic factor for metastasis-free survival and also significant for recurrence-free survival.
Chemotherapy-induced necrosis grading, using only available tumor tissues, could be a prognostic factor for osteosarcoma patients receiving pasteurized autografts for reconstructive surgery.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Analysis</subject><subject>Autografts</subject><subject>Biocompatibility</subject><subject>Biology and Life Sciences</subject><subject>Bone cancer</subject><subject>Bone Transplantation</subject><subject>Care and treatment</subject><subject>Chemotherapy</subject><subject>Child</subject><subject>Control methods</subject><subject>Disease-Free Survival</subject><subject>Drug dosages</subject><subject>Evaluation</subject><subject>Female</subject><subject>Femoral Neoplasms - mortality</subject><subject>Femoral Neoplasms - pathology</subject><subject>Femoral Neoplasms - surgery</subject><subject>Femur</subject><subject>Gangrene</subject><subject>Heat</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Male</subject><subject>Males</subject><subject>Medical prognosis</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>Middle Aged</subject><subject>Necrosis</subject><subject>Osteoblasts</subject><subject>Osteonecrosis - etiology</subject><subject>Osteonecrosis - mortality</subject><subject>Osteonecrosis - pathology</subject><subject>Osteosarcoma</subject><subject>Osteosarcoma - mortality</subject><subject>Osteosarcoma - pathology</subject><subject>Osteosarcoma - surgery</subject><subject>Pasteurization</subject><subject>Patients</subject><subject>Physiological aspects</subject><subject>Plastic surgery</subject><subject>Prognosis</subject><subject>Prostheses</subject><subject>Reconstruction</subject><subject>Reconstructive surgery</subject><subject>Retrospective Studies</subject><subject>Sarcoma</subject><subject>Skin & tissue grafts</subject><subject>Studies</subject><subject>Surgery</subject><subject>Survival</subject><subject>Survival Rate</subject><subject>Tissues</subject><subject>Tumors</subject><subject>Young Adult</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk12L1DAUhoso7rr6D0QLgujFjEnTtOmNsCx-DCys-HUbTtOTTpY2GZN2cf31pk53mcpeLLloOX3eN-mbc5LkOSVrykr67tKN3kK33jmLa0LLjHL-IDmmFctWRUbYw4P3o-RJCJeEcCaK4nFylAlaFTSjx4n_4l1rXRiMSoNprdFGgVWYOp2qLfZu2KKH3fXK2GZU2KQWlXfBhNTYNMrQBfDK9ZDuYDBoh5B6VGiujG1jKQKjN3-iDsbBtR70EJ4mjzR0AZ_Nz5Pkx8cP388-r84vPm3OTs9Xqsz4sKozxSgWmRY5rZq8bPKqBOCiroEwQrHKmworXXPMUQglmrqCmiJBFFpFhJ0kL_e-u84FOccVJBWFyASnVR6JzZ5oHFzKnTc9-GvpwMh_BedbCT4m06FseFEUmdCkBpoXpRaqqgmQRpVMaV6r6PV-3m2se2xUjMJDtzBdfrFmK1t3JTkjQlAeDd7MBt79GjEMsjdBYdeBRTdO5y4zkZeMl_dAi2mxXET01X_o3UHMVAvxX43VLh5RTabyNBexURgnVaTWd1BxNdgbFdtQm1hfCN4uBJEZ8PfQwhiC3Hz7en_24ueSfX3AbhG6YRtcNw7G2bAE8z049WzwqG_vgxI5TdFNGnKaIjlPUZS9OLzLW9HN2LC_sNgaxA</recordid><startdate>20170214</startdate><enddate>20170214</enddate><creator>Joo, Min Wook</creator><creator>Kang, Yong Koo</creator><creator>Yoo, Chang-Young</creator><creator>Cha, Sung Ho</creator><creator>Chung, Yang-Guk</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0001-8153-8205</orcidid></search><sort><creationdate>20170214</creationdate><title>Prognostic significance of chemotherapy-induced necrosis in osteosarcoma patients receiving pasteurized autografts</title><author>Joo, Min Wook ; Kang, Yong Koo ; Yoo, Chang-Young ; Cha, Sung Ho ; Chung, Yang-Guk</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c725t-b2c31e62f8419d47d497aa58bba0301e94d9e9fb5e4e88c8db9ab1e0ee8fca033</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Analysis</topic><topic>Autografts</topic><topic>Biocompatibility</topic><topic>Biology and Life Sciences</topic><topic>Bone cancer</topic><topic>Bone Transplantation</topic><topic>Care and treatment</topic><topic>Chemotherapy</topic><topic>Child</topic><topic>Control methods</topic><topic>Disease-Free Survival</topic><topic>Drug dosages</topic><topic>Evaluation</topic><topic>Female</topic><topic>Femoral Neoplasms - mortality</topic><topic>Femoral Neoplasms - pathology</topic><topic>Femoral Neoplasms - surgery</topic><topic>Femur</topic><topic>Gangrene</topic><topic>Heat</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Male</topic><topic>Males</topic><topic>Medical prognosis</topic><topic>Medicine</topic><topic>Medicine and Health Sciences</topic><topic>Metastases</topic><topic>Metastasis</topic><topic>Middle Aged</topic><topic>Necrosis</topic><topic>Osteoblasts</topic><topic>Osteonecrosis - etiology</topic><topic>Osteonecrosis - mortality</topic><topic>Osteonecrosis - pathology</topic><topic>Osteosarcoma</topic><topic>Osteosarcoma - mortality</topic><topic>Osteosarcoma - pathology</topic><topic>Osteosarcoma - surgery</topic><topic>Pasteurization</topic><topic>Patients</topic><topic>Physiological aspects</topic><topic>Plastic surgery</topic><topic>Prognosis</topic><topic>Prostheses</topic><topic>Reconstruction</topic><topic>Reconstructive surgery</topic><topic>Retrospective Studies</topic><topic>Sarcoma</topic><topic>Skin & tissue grafts</topic><topic>Studies</topic><topic>Surgery</topic><topic>Survival</topic><topic>Survival Rate</topic><topic>Tissues</topic><topic>Tumors</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Joo, Min Wook</creatorcontrib><creatorcontrib>Kang, Yong Koo</creatorcontrib><creatorcontrib>Yoo, Chang-Young</creatorcontrib><creatorcontrib>Cha, Sung Ho</creatorcontrib><creatorcontrib>Chung, Yang-Guk</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Joo, Min Wook</au><au>Kang, Yong Koo</au><au>Yoo, Chang-Young</au><au>Cha, Sung Ho</au><au>Chung, Yang-Guk</au><au>Alonso, Marta M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic significance of chemotherapy-induced necrosis in osteosarcoma patients receiving pasteurized autografts</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2017-02-14</date><risdate>2017</risdate><volume>12</volume><issue>2</issue><spage>e0172155</spage><epage>e0172155</epage><pages>e0172155-e0172155</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Among various reconstruction methods after wide excision for osteosarcoma, pasteurized autograft is often preferred. While the whole area of the tumor can be assessed for chemotherapy-induced necrosis, one of the important prognostic factors, in other reconstructive techniques, only a portion removed from a wide-resection specimen is available when using pasteurized autograft method. The assessment, therefore, may be unreliable. We analyzed the prognostic significance of the chemotherapy-induced necrosis in osteosarcoma patients who underwent reconstruction with pasteurized autografts.
We reviewed the records of osteosarcoma patients who underwent treatment in our institution from 1998 to 2013. Cases of reconstruction with pasteurized autografts were defined as the patient group, and the same number of patients who underwent other reconstruction methods served as controls. Chemotherapy-induced necrosis was evaluated for removed extra-osseous and curetted intramedullary tumor tissues.
A total of 22 patients were identified; the median age was 15.5 years, and there were 12 males. The most common tumor location was the distal femur. The most common histological subtype was osteoblastic. Median size was 8.1 cm. Disease status was stage IIB in 13 patients and IIA in 9. Median follow-up was 76 months. No differences between the patient and control groups were observed in potential prognostic factors, overall survival, metastasis-free survival, or recurrence-free survival. Univariate analyses demonstrated that histological response was a significant prognostic factor for metastasis-free survival and also significant for recurrence-free survival.
Chemotherapy-induced necrosis grading, using only available tumor tissues, could be a prognostic factor for osteosarcoma patients receiving pasteurized autografts for reconstructive surgery.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>28196121</pmid><doi>10.1371/journal.pone.0172155</doi><tpages>e0172155</tpages><orcidid>https://orcid.org/0000-0001-8153-8205</orcidid><oa>free_for_read</oa></addata></record> |
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| issn | 1932-6203 1932-6203 |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Public Library of Science (PLoS) Journals Open Access; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adolescent Adult Aged Aged, 80 and over Analysis Autografts Biocompatibility Biology and Life Sciences Bone cancer Bone Transplantation Care and treatment Chemotherapy Child Control methods Disease-Free Survival Drug dosages Evaluation Female Femoral Neoplasms - mortality Femoral Neoplasms - pathology Femoral Neoplasms - surgery Femur Gangrene Heat Hospitals Humans Male Males Medical prognosis Medicine Medicine and Health Sciences Metastases Metastasis Middle Aged Necrosis Osteoblasts Osteonecrosis - etiology Osteonecrosis - mortality Osteonecrosis - pathology Osteosarcoma Osteosarcoma - mortality Osteosarcoma - pathology Osteosarcoma - surgery Pasteurization Patients Physiological aspects Plastic surgery Prognosis Prostheses Reconstruction Reconstructive surgery Retrospective Studies Sarcoma Skin & tissue grafts Studies Surgery Survival Survival Rate Tissues Tumors Young Adult |
| title | Prognostic significance of chemotherapy-induced necrosis in osteosarcoma patients receiving pasteurized autografts |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-01T19%3A23%3A09IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Prognostic%20significance%20of%20chemotherapy-induced%20necrosis%20in%20osteosarcoma%20patients%20receiving%20pasteurized%20autografts&rft.jtitle=PloS%20one&rft.au=Joo,%20Min%20Wook&rft.date=2017-02-14&rft.volume=12&rft.issue=2&rft.spage=e0172155&rft.epage=e0172155&rft.pages=e0172155-e0172155&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0172155&rft_dat=%3Cgale_plos_%3EA481213509%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1868285194&rft_id=info:pmid/28196121&rft_galeid=A481213509&rft_doaj_id=oai_doaj_org_article_d566628f0ba1467f8c9b0a0dc73cf5bc&rfr_iscdi=true |