Longitudinal change of selected human milk oligosaccharides and association to infants' growth, an observatory, single center, longitudinal cohort study
Human milk is the recommended and sole nutrient source for newborns. One of the largest components of human milk is oligosaccharides (HMOs) with major constituents determined by the mother genotype for the fucosyltransferase 2 (FUT2, secretor) gene. HMO variation has been related with infant microbi...
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| creator | Sprenger, Norbert Lee, Le Ye De Castro, Carlos Antonio Steenhout, Philippe Thakkar, Sagar K |
| description | Human milk is the recommended and sole nutrient source for newborns. One of the largest components of human milk is oligosaccharides (HMOs) with major constituents determined by the mother genotype for the fucosyltransferase 2 (FUT2, secretor) gene. HMO variation has been related with infant microbiota establishment, diarrhea incidence, morbidity and mortality, IgE associated eczema and body composition.
We investigated the (i) dependence of several major representative HMOs on the FUT2 status assessed through breast milk 2'Fucosyllactose (2'FL) and (ii) the relation of the 2'FL status with infant growth up to 4 months of life.
From an open observatory, single center, longitudinal cohort study with quantitative human milk collection at 30, 60, and 120 days postpartum from 50 mothers, who gave birth to 25 female and 25 male singleton infants, we collected a representative sample of human milk. We quantified the following 5 representative HMOs: 2'FL, Lacto-N-tetraose (LNT), Lacto-N-neotetraose (LNnT), 3'Sialyllactose (3'SL) and 6'Sialyllactose (6'SL). We grouped the milk samples and corresponding infants according to the measured milk 2'FL concentrations at 30 days of lactation, which clustered around low concentrations (95% CI of mean 12-42 mg/L) and high concentrations (95% CI of mean 1880-2460 mg/L) with the former likely representing Secretor negative mothers. Infant anthropometric measures were recorded at birth, 1, 2 and 4 months of age. Relations among the quantified HMOs and the relation of the high and low 2'FL HMOs groups with infant growth parameters were investigated via linear mixed models.
The milk samples with low 2'FL concentration had higher LNT and lower LNnT concentrations compared to the samples with high 2'FL. The milk 3'- and 6'SL concentrations were independent of 2'FL. Over lactation time we observed a drop in the concentration of 2'FL, LNT, LNnT and 6'SL, especially from 1 to 2 months, while 3'SL remained at relatively constant concentration from 1 month onwards. Up to 4 months of age, we did not observe significant differences in body weight, body length, body mass index and head circumference of the infants who consumed breast milk with low or high FUT2 associated HMO concentrations and composition.
Our findings on HMO concentrations over time of lactation and clusters based on 2'FL concentrations confirm previous observations and suggest that LNnT and LNT are 'co-regulated' with the FUT2 dependent 2'FL concentration, with LNnT sho |
| doi_str_mv | 10.1371/journal.pone.0171814 |
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We investigated the (i) dependence of several major representative HMOs on the FUT2 status assessed through breast milk 2'Fucosyllactose (2'FL) and (ii) the relation of the 2'FL status with infant growth up to 4 months of life.
From an open observatory, single center, longitudinal cohort study with quantitative human milk collection at 30, 60, and 120 days postpartum from 50 mothers, who gave birth to 25 female and 25 male singleton infants, we collected a representative sample of human milk. We quantified the following 5 representative HMOs: 2'FL, Lacto-N-tetraose (LNT), Lacto-N-neotetraose (LNnT), 3'Sialyllactose (3'SL) and 6'Sialyllactose (6'SL). We grouped the milk samples and corresponding infants according to the measured milk 2'FL concentrations at 30 days of lactation, which clustered around low concentrations (95% CI of mean 12-42 mg/L) and high concentrations (95% CI of mean 1880-2460 mg/L) with the former likely representing Secretor negative mothers. Infant anthropometric measures were recorded at birth, 1, 2 and 4 months of age. Relations among the quantified HMOs and the relation of the high and low 2'FL HMOs groups with infant growth parameters were investigated via linear mixed models.
The milk samples with low 2'FL concentration had higher LNT and lower LNnT concentrations compared to the samples with high 2'FL. The milk 3'- and 6'SL concentrations were independent of 2'FL. Over lactation time we observed a drop in the concentration of 2'FL, LNT, LNnT and 6'SL, especially from 1 to 2 months, while 3'SL remained at relatively constant concentration from 1 month onwards. Up to 4 months of age, we did not observe significant differences in body weight, body length, body mass index and head circumference of the infants who consumed breast milk with low or high FUT2 associated HMO concentrations and composition.
Our findings on HMO concentrations over time of lactation and clusters based on 2'FL concentrations confirm previous observations and suggest that LNnT and LNT are 'co-regulated' with the FUT2 dependent 2'FL concentration, with LNnT showing a positive and LNT a negative relation. Further, our findings also suggest that the relatively substantial variation in HMOs between the high and low 2'FL clusters do not impact infant growth of either sex up to 4 months of age. The study was registered in www.ClinicalTrial.gov (NCT01805011).</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0171814</identifier><identifier>PMID: 28182762</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Age ; Anthropometry ; Babies ; Baby foods ; Biology and Life Sciences ; Birth ; Blood groups ; Body composition ; Body length ; Body mass ; Body mass index ; Body measurements ; Body size ; Body weight ; Breast Feeding ; Breast milk ; Breastfeeding & lactation ; Child Development - physiology ; Clusters ; Cohort analysis ; Diabetes ; Diarrhea ; Eczema ; Enzymes ; Female ; Galactoside 2-a-L-fucosyltransferase ; Genotypes ; Growth ; Health aspects ; Humans ; Infant ; Infant, Newborn ; Infants ; Lactation ; Lactation - metabolism ; Lactose ; Longitudinal Studies ; Low concentrations ; Male ; Medicine and Health Sciences ; Microbiota ; Milk ; Milk, Human - chemistry ; Milk, Human - metabolism ; Morbidity ; Mothers ; Neonates ; Nutrition ; Oligosaccharides ; Oligosaccharides - analysis ; Oligosaccharides - metabolism ; Pediatrics ; People and Places ; Physiological aspects ; Population ; Postpartum ; Skin diseases ; Social Sciences ; Young Adult</subject><ispartof>PloS one, 2017-02, Vol.12 (2), p.e0171814-e0171814</ispartof><rights>COPYRIGHT 2017 Public Library of Science</rights><rights>2017 Sprenger et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2017 Sprenger et al 2017 Sprenger et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c791t-e1385af6f9f347761b65d07b78a53a2186addb74efb3f9a8aad2fde2eaaf257e3</citedby><cites>FETCH-LOGICAL-c791t-e1385af6f9f347761b65d07b78a53a2186addb74efb3f9a8aad2fde2eaaf257e3</cites><orcidid>0000-0003-4880-2750</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5300226/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5300226/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28182762$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sprenger, Norbert</creatorcontrib><creatorcontrib>Lee, Le Ye</creatorcontrib><creatorcontrib>De Castro, Carlos Antonio</creatorcontrib><creatorcontrib>Steenhout, Philippe</creatorcontrib><creatorcontrib>Thakkar, Sagar K</creatorcontrib><title>Longitudinal change of selected human milk oligosaccharides and association to infants' growth, an observatory, single center, longitudinal cohort study</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Human milk is the recommended and sole nutrient source for newborns. One of the largest components of human milk is oligosaccharides (HMOs) with major constituents determined by the mother genotype for the fucosyltransferase 2 (FUT2, secretor) gene. HMO variation has been related with infant microbiota establishment, diarrhea incidence, morbidity and mortality, IgE associated eczema and body composition.
We investigated the (i) dependence of several major representative HMOs on the FUT2 status assessed through breast milk 2'Fucosyllactose (2'FL) and (ii) the relation of the 2'FL status with infant growth up to 4 months of life.
From an open observatory, single center, longitudinal cohort study with quantitative human milk collection at 30, 60, and 120 days postpartum from 50 mothers, who gave birth to 25 female and 25 male singleton infants, we collected a representative sample of human milk. We quantified the following 5 representative HMOs: 2'FL, Lacto-N-tetraose (LNT), Lacto-N-neotetraose (LNnT), 3'Sialyllactose (3'SL) and 6'Sialyllactose (6'SL). We grouped the milk samples and corresponding infants according to the measured milk 2'FL concentrations at 30 days of lactation, which clustered around low concentrations (95% CI of mean 12-42 mg/L) and high concentrations (95% CI of mean 1880-2460 mg/L) with the former likely representing Secretor negative mothers. Infant anthropometric measures were recorded at birth, 1, 2 and 4 months of age. Relations among the quantified HMOs and the relation of the high and low 2'FL HMOs groups with infant growth parameters were investigated via linear mixed models.
The milk samples with low 2'FL concentration had higher LNT and lower LNnT concentrations compared to the samples with high 2'FL. The milk 3'- and 6'SL concentrations were independent of 2'FL. Over lactation time we observed a drop in the concentration of 2'FL, LNT, LNnT and 6'SL, especially from 1 to 2 months, while 3'SL remained at relatively constant concentration from 1 month onwards. Up to 4 months of age, we did not observe significant differences in body weight, body length, body mass index and head circumference of the infants who consumed breast milk with low or high FUT2 associated HMO concentrations and composition.
Our findings on HMO concentrations over time of lactation and clusters based on 2'FL concentrations confirm previous observations and suggest that LNnT and LNT are 'co-regulated' with the FUT2 dependent 2'FL concentration, with LNnT showing a positive and LNT a negative relation. Further, our findings also suggest that the relatively substantial variation in HMOs between the high and low 2'FL clusters do not impact infant growth of either sex up to 4 months of age. The study was registered in www.ClinicalTrial.gov (NCT01805011).</description><subject>Adult</subject><subject>Age</subject><subject>Anthropometry</subject><subject>Babies</subject><subject>Baby foods</subject><subject>Biology and Life Sciences</subject><subject>Birth</subject><subject>Blood groups</subject><subject>Body composition</subject><subject>Body length</subject><subject>Body mass</subject><subject>Body mass index</subject><subject>Body measurements</subject><subject>Body size</subject><subject>Body weight</subject><subject>Breast Feeding</subject><subject>Breast milk</subject><subject>Breastfeeding & lactation</subject><subject>Child Development - physiology</subject><subject>Clusters</subject><subject>Cohort analysis</subject><subject>Diabetes</subject><subject>Diarrhea</subject><subject>Eczema</subject><subject>Enzymes</subject><subject>Female</subject><subject>Galactoside 2-a-L-fucosyltransferase</subject><subject>Genotypes</subject><subject>Growth</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Infants</subject><subject>Lactation</subject><subject>Lactation - metabolism</subject><subject>Lactose</subject><subject>Longitudinal Studies</subject><subject>Low concentrations</subject><subject>Male</subject><subject>Medicine and Health Sciences</subject><subject>Microbiota</subject><subject>Milk</subject><subject>Milk, Human - chemistry</subject><subject>Milk, Human - metabolism</subject><subject>Morbidity</subject><subject>Mothers</subject><subject>Neonates</subject><subject>Nutrition</subject><subject>Oligosaccharides</subject><subject>Oligosaccharides - analysis</subject><subject>Oligosaccharides - metabolism</subject><subject>Pediatrics</subject><subject>People and Places</subject><subject>Physiological aspects</subject><subject>Population</subject><subject>Postpartum</subject><subject>Skin diseases</subject><subject>Social Sciences</subject><subject>Young Adult</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk9tqFTEUhgdRbK2-gWhA8ADd2xxmJjM3QikeCoWCp9uwJpPMpGYnNclU-yY-rhm7WzrSi5KLnL7_T7JWVlE8JXhNGCdvT_0UHNj1mXdqjQknDSnvFbukZXRVU8zu3xjvFI9iPMW4Yk1dPyx2aEMaymu6W_w59m4waepN9kJyBDco5DWKyiqZVI_GaQMObYz9gbw1g48gMxVMryIC1yOI0UsDyXiHkkfGaXApvkJD8L_SuJ8Z5LuowjkkHy72UTRusApJ5ZIK-8gujvejDwnFPL94XDzQYKN6su33im8f3n89_LQ6Pvl4dHhwvJK8JWmlCGsq0LVuNSs5r0lXVz3mHW-gYkBJU0Pfd7xUumO6hQagp7pXVAFoWnHF9ornl75n1kexDWoUWVjXDPOqzMTRJdF7OBVnwWwgXAgPRvxb8GEQEJKRVglZM5ntuSZEl23Xd1IrqHBDWYu5wix7vdueNnUb1c9RCGAXpssdZ0Yx-HNRMYwprbPB661B8D8nFZPYmCiVteCUn-Z7c9qwilfVHdB6fl6JaUZf_IfeHogtNUB-a860z1eUs6k4KBuCWcv5TK1voXLr1cbI_Fm1yesLwZuFIDNJ_U4DTDGKoy-f786efF-yL2-wowKbxujtNH_VuATLS1AGH2NQ-jofBIu51q6iIeZaE9tay7JnN3N5LboqLvYXk-gn9g</recordid><startdate>20170209</startdate><enddate>20170209</enddate><creator>Sprenger, Norbert</creator><creator>Lee, Le Ye</creator><creator>De Castro, Carlos Antonio</creator><creator>Steenhout, Philippe</creator><creator>Thakkar, Sagar K</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0003-4880-2750</orcidid></search><sort><creationdate>20170209</creationdate><title>Longitudinal change of selected human milk oligosaccharides and association to infants' growth, an observatory, single center, longitudinal cohort study</title><author>Sprenger, Norbert ; Lee, Le Ye ; De Castro, Carlos Antonio ; Steenhout, Philippe ; Thakkar, Sagar K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c791t-e1385af6f9f347761b65d07b78a53a2186addb74efb3f9a8aad2fde2eaaf257e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Age</topic><topic>Anthropometry</topic><topic>Babies</topic><topic>Baby foods</topic><topic>Biology and Life Sciences</topic><topic>Birth</topic><topic>Blood groups</topic><topic>Body composition</topic><topic>Body length</topic><topic>Body mass</topic><topic>Body mass index</topic><topic>Body measurements</topic><topic>Body size</topic><topic>Body weight</topic><topic>Breast Feeding</topic><topic>Breast milk</topic><topic>Breastfeeding & lactation</topic><topic>Child Development - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sprenger, Norbert</au><au>Lee, Le Ye</au><au>De Castro, Carlos Antonio</au><au>Steenhout, Philippe</au><au>Thakkar, Sagar K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Longitudinal change of selected human milk oligosaccharides and association to infants' growth, an observatory, single center, longitudinal cohort study</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2017-02-09</date><risdate>2017</risdate><volume>12</volume><issue>2</issue><spage>e0171814</spage><epage>e0171814</epage><pages>e0171814-e0171814</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Human milk is the recommended and sole nutrient source for newborns. One of the largest components of human milk is oligosaccharides (HMOs) with major constituents determined by the mother genotype for the fucosyltransferase 2 (FUT2, secretor) gene. HMO variation has been related with infant microbiota establishment, diarrhea incidence, morbidity and mortality, IgE associated eczema and body composition.
We investigated the (i) dependence of several major representative HMOs on the FUT2 status assessed through breast milk 2'Fucosyllactose (2'FL) and (ii) the relation of the 2'FL status with infant growth up to 4 months of life.
From an open observatory, single center, longitudinal cohort study with quantitative human milk collection at 30, 60, and 120 days postpartum from 50 mothers, who gave birth to 25 female and 25 male singleton infants, we collected a representative sample of human milk. We quantified the following 5 representative HMOs: 2'FL, Lacto-N-tetraose (LNT), Lacto-N-neotetraose (LNnT), 3'Sialyllactose (3'SL) and 6'Sialyllactose (6'SL). We grouped the milk samples and corresponding infants according to the measured milk 2'FL concentrations at 30 days of lactation, which clustered around low concentrations (95% CI of mean 12-42 mg/L) and high concentrations (95% CI of mean 1880-2460 mg/L) with the former likely representing Secretor negative mothers. Infant anthropometric measures were recorded at birth, 1, 2 and 4 months of age. Relations among the quantified HMOs and the relation of the high and low 2'FL HMOs groups with infant growth parameters were investigated via linear mixed models.
The milk samples with low 2'FL concentration had higher LNT and lower LNnT concentrations compared to the samples with high 2'FL. The milk 3'- and 6'SL concentrations were independent of 2'FL. Over lactation time we observed a drop in the concentration of 2'FL, LNT, LNnT and 6'SL, especially from 1 to 2 months, while 3'SL remained at relatively constant concentration from 1 month onwards. Up to 4 months of age, we did not observe significant differences in body weight, body length, body mass index and head circumference of the infants who consumed breast milk with low or high FUT2 associated HMO concentrations and composition.
Our findings on HMO concentrations over time of lactation and clusters based on 2'FL concentrations confirm previous observations and suggest that LNnT and LNT are 'co-regulated' with the FUT2 dependent 2'FL concentration, with LNnT showing a positive and LNT a negative relation. Further, our findings also suggest that the relatively substantial variation in HMOs between the high and low 2'FL clusters do not impact infant growth of either sex up to 4 months of age. The study was registered in www.ClinicalTrial.gov (NCT01805011).</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>28182762</pmid><doi>10.1371/journal.pone.0171814</doi><tpages>e0171814</tpages><orcidid>https://orcid.org/0000-0003-4880-2750</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2017-02, Vol.12 (2), p.e0171814-e0171814 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1866630754 |
| source | Public Library of Science (PLoS) Journals Open Access; MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adult Age Anthropometry Babies Baby foods Biology and Life Sciences Birth Blood groups Body composition Body length Body mass Body mass index Body measurements Body size Body weight Breast Feeding Breast milk Breastfeeding & lactation Child Development - physiology Clusters Cohort analysis Diabetes Diarrhea Eczema Enzymes Female Galactoside 2-a-L-fucosyltransferase Genotypes Growth Health aspects Humans Infant Infant, Newborn Infants Lactation Lactation - metabolism Lactose Longitudinal Studies Low concentrations Male Medicine and Health Sciences Microbiota Milk Milk, Human - chemistry Milk, Human - metabolism Morbidity Mothers Neonates Nutrition Oligosaccharides Oligosaccharides - analysis Oligosaccharides - metabolism Pediatrics People and Places Physiological aspects Population Postpartum Skin diseases Social Sciences Young Adult |
| title | Longitudinal change of selected human milk oligosaccharides and association to infants' growth, an observatory, single center, longitudinal cohort study |
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