Farnesylthiosalicylic acid sensitizes hepatocarcinoma cells to artemisinin derivatives

Dihydroartemisinin (DHA) and artesunate (ARS), two artemisinin derivatives, have efficacious anticancer activities against human hepatocarcinoma (HCC) cells. This study aims to study the anticancer action of the combination treatment of DHA/ARS and farnesylthiosalicylic acid (FTS), a Ras inhibitor,...

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Veröffentlicht in:	PloS one 2017-02, Vol.12 (2), p.e0171840-e0171840
Hauptverfasser:	Wu, Liping, Pang, Yilin, Qin, Guiqi, Xi, Gaina, Wu, Shengnan, Wang, Xiaoping, Chen, Tongsheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcysteine Acetylcysteine - pharmacology Acids Activation Anticancer properties Antineoplastic Agents - pharmacology Antioxidants Apoptosis Apoptosis - drug effects Artemisinin Artemisinins - pharmacology Artemisinins - toxicity Artesunate Bax protein Biology and Life Sciences Cancer therapies Carcinoma, Hepatocellular - metabolism Care and treatment Caspase Caspase-8 Cell cycle Cell lines Chemotherapy Cytochrome Cytochrome c Cytotoxicity Depolarization Derivatives Dihydroartemisinin Drug Synergism Drugs Farnesol - analogs & derivatives Farnesol - pharmacology Feedback Hep G2 Cells Hepatocellular carcinoma Hepatoma Humans Inhibition Inhibitors Laboratories Lasers Leukemia Life sciences Liver cancer Liver Neoplasms - metabolism Medicine and Health Sciences Membrane potential Mitochondria Oxygen Pancreatic cancer Phosphatidylserine Pretreatment Prostate cancer Radiation therapy Reactive oxygen species Research and Analysis Methods Salicylates - pharmacology Toxicity
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